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Home Page > Alphabetical Index > COBROTOXIN (α-)

COBROTOXIN (α-) Prod. No L8114 - CAS # 12584-83-7
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Product Name COBROTOXIN (α-)
(Syn.: Neurotoxin III; Monocellate cobratoxin; α-Cobratoxin; Long neurotoxin 1)
Product Code L8114
COBROTOXIN (α-)
Molecular Formula
Description

a high affinity nicotinic receptor antagonist; a long chain postsynaptic neurotoxin.

71-amino acid polypeptide with 5 disulfide bridges ‚ from Naja naja kaouthia (siamensis) snake venom.
 
Biological Activity

nicotinic cholinoreceptor antagonist: Kd = 55 pM [1].

homologue of postsynaptically acting toxins.
 
Chemical and Physical Properties
 
CAS No. 12584-83-7 Molecular Weight 7‚820 Da.
RTECS Physical Form white solid.
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity 99%. (capillary electrophoresis) Optical Activity
Toxicity (LD50) LD100 mice (i.v.): 100 µg/kg [4].
Chemical Names
Storage & Reconstitution Recommendations stable in dry state; store in a dark place. Keep the solution at -20 °C.
Safety Recommendations
 
Bibliographic References
  1. Ishikawa Y. et al., Toxicon (1977). 15:477-488
  2. Charpentier I. et al., J. of Molecular Recognition (1990). 3:74-81
  3. Faure G. et al., Biochemistry (1983). 22:2068-2076
  4. Karlsson E. et al.,"Isolation of the principal neurotoxins of Naja naja subspecies from the asian mainland." Toxicon (1972). 10:217-225
  5. Walkinshaw M.D. et al., Proc. Natl. Acad. Sci. USA (1980). 77:2400-2404
  6. Betzel C. et al., J. Biol. Chem. (1991). 266:21530-21536
 
Prices
Code
Quantity
US $
€uro
L8114
1 x 1 mg
176.40
126.00
5 x 1 mg
705.60
504.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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