 |


ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

|
|

| | L8114 aCOBROTOXIN
|
| ( Neurotoxin III; Monocellate cobratoxin; alpha-Cobratoxin; Long neurotoxin 1 ) |
a high affinity nicotinic receptor antagonist; a long chain postsynaptic neurotoxin.
|
71-amino acid polypeptide with 5 disulfide bridges from Naja naja kaouthia (siamensis) snake venom.
|

| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 176.40 | 126.00 |
5 x 1 mg | 705.60 | 504.00 |
- Molecular Weight : 7,820 Da.
- Solubility in : well in water and saline.
- Purity min. : 99%. (capillary electrophoresis)
- Physical Form : white solid.
- Biological Activity : nicotinic cholinoreceptor antagonist: Kd = 55 pM [1].
homologue of postsynaptically acting toxins.
- Toxicity (LD50) : LD100 mice (i.v.): 100 µg/kg [4].
- Storage recommendations : stable in dry state; store in a dark place. Keep the solution at -20 °C.
- CAS Reg. No. : 12584-83-7
- Bibliography :
- Ishikawa Y. et al., Toxicon (1977). 15:477-488
- Charpentier I. et al., J. of Molecular Recognition (1990). 3:74-81
- Faure G. et al., Biochemistry (1983). 22:2068-2076
- Karlsson E. et al.,"Isolation of the principal neurotoxins of Naja naja subspecies from the asian mainland." Toxicon (1972). 10:217-225
- Walkinshaw M.D. et al., Proc. Natl. Acad. Sci. USA (1980). 77:2400-2404
- Betzel C. et al., J. Biol. Chem. (1991). 266:21530-21536
|
|
Latoxan - 20, Rue Léon Blum - F-26000 VALENCE - France Phone: +33.4.75.41.91.91 - Fax: +33.4.75.41.91.99
contact@latoxan.com
For Research Purposes Only - Not for Human Use. |
Revised : 26/04/2007 10:27 - Copyright © Latoxan |
|