a high affinity nicotinic receptor antagonist; a long chain postsynaptic neurotoxin.

71-amino acid polypeptide with 5 disulfide bridges from Naja naja kaouthia (siamensis) snake venom.

• Molecular Weight : 7,820 Da.
  
  
• Solubility in : well in water and saline.
  
  
• Purity min. : 99%. (capillary electrophoresis)
  
  
• Physical Form : white solid.
  
  
• Biological Activity : nicotinic cholinoreceptor antagonist: Kd = 55 pM [1].
  homologue of postsynaptically acting toxins.
  
  
• Toxicity (LD₅₀) : LD100 mice (i.v.): 100 µg/kg [4].
  
  
• Storage recommendations : stable in dry state; store in a dark place. Keep the solution at -20 °C.
  
  
• CAS Reg. No. : 12584-83-7
  
  
• Bibliography :
  
  1. Ishikawa Y. et al., Toxicon (1977). 15:477-488
  2. Charpentier I. et al., J. of Molecular Recognition (1990). 3:74-81
  3. Faure G. et al., Biochemistry (1983). 22:2068-2076
  4. Karlsson E. et al.,"Isolation of the principal neurotoxins of Naja naja subspecies from the asian mainland." Toxicon (1972). 10:217-225
  5. Walkinshaw M.D. et al., Proc. Natl. Acad. Sci. USA (1980). 77:2400-2404
  6. Betzel C. et al., J. Biol. Chem. (1991). 266:21530-21536