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Home Page > Alphabetical Index > CHARYBDOTOXIN (Native)

CHARYBDOTOXIN (Native) Prod. No L8201 - CAS # 115422-61-2
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Product Name CHARYBDOTOXIN (Native)
Product Code L8201
CHARYBDOTOXIN (Native)
Molecular Formula
Description

a blocker of large conductance Ca2+– activated K+ channels and other K+ channels.

37-amino acid peptide with 3 disulfide bridges‚ purified ‚ from Leiurus quinquestriatus scorpion venom.
 
Biological Activity

 
Chemical and Physical Properties
 
CAS No. 115422-61-2 Molecular Weight 4296 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID 196925 Solubility well in saline.
Purity 98.5 % (HPLC) Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations Charybdotoxin (native) is packaged under Argon and the amount of protein as determined by UV spectra was checked after repartition and lyophilisation by amino acid analysis. The mean variation percentage in weight is less than 5%.
lyophilized Charybdotoxin (native) can be kept at 4 °C. It should be reconstituted in saline solution (about 150 mM salt is recommended); use only glass or pyrex but not plastic containers‚ as it has a tendency to stick to different kinds of materials at low salt concentration. Though exceptionnally stable (3)‚ the unused peptide should then be relyophilized or stored at -20 °C.
Safety Recommendations
 
Bibliographic References
  1. Miller et al., Nature (1985) 313:316-318
  2. Gimenez-Gallego et al., Proc. Natl. Acad. Sci. (1988). 85:3329-3333
  3. Smith et al., C. J. Biol. Chem.(1986). 261:14607-14613
  4. Vita et al., "Synthesis of Charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterisation." Eur. J. Biochem. (1993) 217: 157-169
 
Prices
Code
Quantity
US $
€uro
L8201
1 x 10 µg
75.60
54.00
5 x 10 µg
302.40
216.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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