IMPERATOXIN-INHIBITOR (IpTxi) - LATOXAN Technical Data Sheet
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ION CHANNEL and RECEPTOR LIGANDS
TOXINS & ALKALOIDS

 
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L8203 IMPERATOXIN-INHIBITOR (IpTxi)

an inhibitor of Ca2+-release channels from sarcoplasmic reticulum.

Polypeptide from Pandinus imperator scorpion venom.

PRICES
QuantityUS DollarsEURO
10 µg 354.20 253.00
5 x 10 µg1 416.801 012.00


  • Molecular Weight : 10 KDa.

  • Solubility in : water, non-polar solvents (methanol, acetonitrile).

  • Purity min. : 90 % (SDS-PAGE and HPLC).

  • Biological Activity : The toxin inhibits, with an apparent K in the nM range, ryanodine binding to the receptor both in cardiac and skeletal muscle, and it inhibits Ca2+ release from skeletal SR vesicles in the presence of micromolar extravesicular [Ca2+].

  • Storage recommendations : resuspend in buffer at pH 5-7. Store at -20°C. Avoid multiple freeze-thaw cycles.

  • Bibliography :
    1. Valdivia et al., "Sorpion toxins targeted against the sarcoplasmic reticulum Ca2+- release channel of skeletal and cardiac muscle." Proc. Nat. Acad. Sci. USA. (1992) 89:12185-12189



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan