an inhibitor of Ca²⁺-release channels from sarcoplasmic reticulum.

Polypeptide from Pandinus imperator scorpion venom.

• Molecular Weight : 10 KDa.
  
  
• Solubility in : water, non-polar solvents (methanol, acetonitrile).
  
  
• Purity min. : 90 % (SDS-PAGE and HPLC).
  
  
• Biological Activity : The toxin inhibits, with an apparent K in the nM range, ryanodine binding to the receptor both in cardiac and skeletal muscle, and it inhibits Ca²⁺ release from skeletal SR vesicles in the presence of micromolar extravesicular [Ca²⁺].
  
  
• Storage recommendations : resuspend in buffer at pH 5-7. Store at -20°C. Avoid multiple freeze-thaw cycles.
  
  
• Bibliography :
  
  1. Valdivia et al., "Sorpion toxins targeted against the sarcoplasmic reticulum Ca²⁺- release channel of skeletal and cardiac muscle." Proc. Nat. Acad. Sci. USA. (1992) 89:12185-12189