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Home Page > Alphabetical Index > IMPERATOXIN-INHIBITOR (IpTxi)

IMPERATOXIN-INHIBITOR (IpTxi) Prod. No L8203 - CAS #
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Product Name IMPERATOXIN-INHIBITOR (IpTxi)
Product Code L8203
IMPERATOXIN-INHIBITOR (IpTxi)
Molecular Formula
Description

an inhibitor of Ca2+-release channels from sarcoplasmic reticulum.

Polypeptide ‚ from Pandinus imperator scorpion venom.
 
Biological Activity

The toxin inhibits‚ with an apparent K in the nM range‚ ryanodine binding to the receptor both in cardiac and skeletal muscle‚ and it inhibits Ca2+ release from skeletal SR vesicles in the presence of micromolar extravesicular [Ca2+].
 
Chemical and Physical Properties
 
CAS No. Molecular Weight 10 KDa.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility water‚ non-polar solvents (methanol‚ acetonitrile).
Purity 90 % (SDS-PAGE and HPLC). Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations resuspend in buffer at pH 5-7. Store at -20°C. Avoid multiple freeze-thaw cycles.
Safety Recommendations
 
Bibliographic References
  1. Valdivia et al., "Sorpion toxins targeted against the sarcoplasmic reticulum Ca2+- release channel of skeletal and cardiac muscle." Proc. Nat. Acad. Sci. USA. (1992) 89:12185-12189
 
Prices
Code
Quantity
US $
€uro
L8203
1 x 10 µg
354.20
253.00
5 x 10 µg
1 416.80
1 012.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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