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Home Page > Alphabetical Index > KALIOTOXIN (KTX)

KALIOTOXIN (KTX) Prod. No L8208 - CAS # 145199-73-1
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Product Name KALIOTOXIN (KTX)
Product Code L8208
KALIOTOXIN (KTX)

Molecular Formula
Description

a blocker of Ca2+-activated K+ channels of high conductance and some voltage-dependent K+ channels; in human and murin β-lymphocytes‚ where both K+ channels subtypes are present‚ Kaliotoxin is a selective voltage-dependent K+ channels blocker.

38-amino acid peptide with 3 disulfide bridges. ‚ synthetic‚ originally from Androctonus mauretanicus mauretanicus scorpion venom.

 
Biological Activity

Neurons: KTX blocks the invertebrate and mammalian sympathetic high conductance K+ channels with a Kd of 2 to 4 nM. These effects were observed on the whole-cell current as well as on the unitary channel activity.

KTX inhibits the shaker K+ current resulting from mRNA expression in Xenopus oocyte with a Kd of 2 to 5 nM.

The radiolabelled derivative 125I KTX binds to the rat brain synaptosomal membrane (Kd = 10 pM) and it is displaced by Dendrotoxin with a Kd of 8 pM.



Muscle: KTX is poorly active on skeletal high conductance K+ channels incorporated in lipid bilayers.



Lymphocytes: in human and murin b-lymphocytes‚ where both Ca2+-activated K+ channels and voltage-dependent K+ channels are present‚ KTX selectively inhibits the activity of the voltage-dependent K+ channels with a Kd of 1 to 5 nM.

 
Chemical and Physical Properties
 
CAS No. 145199-73-1 Molecular Weight 4‚150.0 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity 98 % (HPLC‚ mass spectrometry). Optical Activity
Toxicity (LD50) mice (intracerebroventricularly): 1.20 to 1.55 µg/kg.
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state. In solution‚ keep at -20 °C.
Safety Recommendations
 
Bibliographic References
  1. Crest et al., "Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca2+-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom." J. Biol. Chem. (1992). 267(3):1640-1647
 
Prices
Code
Quantity
US $
€uro
L8208
1 x 20 µg
96.60
69.00
5 x 20 µg
386.40
276.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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