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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L8208 KALIOTOXIN (KTX)
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a blocker of Ca2+-activated K+ channels of high conductance and some voltage-dependent K+ channels; in human and murin blymphocytes, where both K+ channels subtypes are present, Kaliotoxin is a selective voltage-dependent K+ channels blocker.
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38-amino acid peptide with 3 disulfide bridges. Synthetic, originally from Androctonus mauretanicus mauretanicus scorpion venom.
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| PRICES |
| Quantity | US Dollars | EURO |
20 µg | 96.60 | 69.00 |
5 x 20 µg | 386.40 | 276.00 |
- Molecular Weight : 4,150.0 Da.
- Solubility in : well in water and saline.
- Purity min. : 98 % (HPLC, mass spectrometry).
- Biological Activity : Neurons: KTX blocks the invertebrate and mammalian sympathetic high conductance K+ channels with a Kd of 2 to 4 nM. These effects were observed on the whole-cell current as well as on the unitary channel activity.
KTX inhibits the shaker K+ current resulting from mRNA expression in Xenopus oocyte with a Kd of 2 to 5 nM.
The radiolabelled derivative 125I KTX binds to the rat brain synaptosomal membrane (Kd = 10 pM) and it is displaced by Dendrotoxin with a Kd of 8 pM.
Muscle: KTX is poorly active on skeletal high conductance K+ channels incorporated in lipid bilayers.
Lymphocytes: in human and murin b-lymphocytes, where both Ca2+-activated K+ channels and voltage-dependent K+ channels are present, KTX selectively inhibits the activity of the voltage-dependent K+ channels with a Kd of 1 to 5 nM.
- Toxicity (LD50) : mice (intracerebroventricularly): 1.20 to 1.55 µg/kg.
- Storage recommendations : stable in freeze-dried state. In solution, keep at -20 °C.
- CAS Reg. No. : 145199-73-1
- Bibliography :
- Crest et al., "Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca2+-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom." J. Biol. Chem. (1992). 267(3):1640-1647
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Revised : 26/04/2007 10:27 - Copyright © Latoxan |
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