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Home Page > Alphabetical Index > CHARYBDOTOXIN (Synthetic)

CHARYBDOTOXIN (Synthetic) Prod. No L8213 - CAS # 115422-61-2
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Product Name CHARYBDOTOXIN (Synthetic)
Product Code L8213
CHARYBDOTOXIN (Synthetic)
Molecular Formula
Description

a blocker of large conductance Ca2+– activated K+ channels and other K+ channels.

37-amino acid peptide with 3 disulfide bridges. Synthetic‚ originally from Leiurus quinquestriatus scorpion venom.
 
Biological Activity

 
Chemical and Physical Properties
 
CAS No. 115422-61-2 Molecular Weight 4‚296 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID 196925 Solubility soluble in saline.
Purity 99 % (HPLC). Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations lyophilized Charybdotoxin can be kept at 4 °C. It should be reconstituted in saline solution (about 150 mM salt is recommended); use only glass or pyrex but not plastic containers‚ as Charybdotoxin has a tendency to stick to different kinds of materials at low salt concentration. Though exceptionnally stable (3)‚ the unused peptide should then be relyophilized or stored at -20 °C.
Safety Recommendations
 
Bibliographic References
  1. Miller et al., Nature (1985) 313:316-318
  2. Gimenez-Gallego et al., Proc. Natl. Acad. Sci. (1988). 85:3329-3333
  3. Smith et al., C. J. Biol. Chem.(1986). 261:14607-14613
  4. Vita et al., "Synthesis of Charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterisation." Eur. J. Biochem. (1993) 217:157-169
 
Prices
Code
Quantity
US $
€uro
L8213
1 x 50 µg
121.80
87.00
5 x 50 µg
487.20
348.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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