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Home Page > Alphabetical Index > MCD PEPTIDE

MCD PEPTIDE Prod. No L8402 - CAS # 32908-73-9
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Product Name MCD PEPTIDE
Product Code L8402
MCD PEPTIDE
Molecular Formula
Description

a blocker of voltage-sensitive K+ channels with potent convulsant activity.

22-amino acid peptide with a strongly basic character and 2 disulfide bridges‚ ‚ from Apis mellifera bee venom.
 
Biological Activity

Mast cell degranulating activity: causes histamine release with half-maximal effects in rat peritoneal mast cell preparations at concentrations of 2 X 10-8 M.

MCD Peptide binds with high affinity (Kd = 150 pM) to rat synaptic membranes. This binding induces the inhibition of a voltage sensitive K+ current and produces hippocampal responses (long term potentiation‚ Theta rhythm and epileptiform seizures).
 
Chemical and Physical Properties
 
CAS No. 32908-73-9 Molecular Weight 2‚593 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity (percent by weight)

MCD Peptide: 65 Peptidic contaminants: 2

Acetate: 18 H2O: 15		 Optical Activity
Toxicity (LD50) mice (intracerebroventricularly): 1.5 ng/g.

rats (intracerebroventricularly): 6.8 ng/g.
Chemical Names
Storage & Reconstitution Recommendations 125 µl of distilled water added to a 50 µg vial gives a 100 µM MCD Peptide solution. Store preferably at -20°C. The solution can be freezed and thawed.
Safety Recommendations
 
Bibliographic References
  1. Taylor et al., J. Biol. Chem. (1984). 259:13957-13967
  2. Bidard et al. Brain Res. (1987). 418:235-244
  3. Cherubini et al., Nature (1987) 328:70-73
 
Prices
Code
Quantity
US $
€uro
L8402
1 x 50 µg
151.20
108.00
5 x 50 µg
604.80
432.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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