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Home Page > Alphabetical Index > MELITTIN

MELITTIN Prod. No L8403 - CAS # 20449-79-0
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Product Name MELITTIN
Product Code L8403
MELITTIN
Molecular Formula
Description

an inhibitor of protein-kinases and cell membrane lytic factor from the venom of the Honeybee‚ Apis mellifera.

26-amino acid peptide with no disulfide bridge‚ ‚ from Apis mellifera bee venom; the NH2 terminal part of the molecule is predominantly hydrophobic and the C terminal part is hydrophilic and strongly basic.
 
Biological Activity

inhibitor of protein kinase C‚ Ca2+/calmodulin-dependent protein kinase II‚ myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane)‚ with an IC50 of 1-4 µM; cell membrane lytic factor.
 
Chemical and Physical Properties
 
CAS No. 20449-79-0 Molecular Weight 2‚847 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity Percent by weight:

Melittin: 67 Peptidic contaminants: 9

Acetate: 9 H20: 15

Phospholipase max.: 0.01

Percent by mole:

Phospholipase max.: 0.002		 Optical Activity
Toxicity (LD50) mice (i.p.): 12 µg/g.

mice (intracisternal injection): 0.86 µg/g.
Chemical Names
Storage & Reconstitution Recommendations store preferably at -20°C; solution for use: 100 µM; the solution can be freezed and thawed.
Safety Recommendations
 
Bibliographic References
  1. Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5):2753-2758
  2. Schweitz, "Lethal potency in mice of toxins from scorpion, sea anemone, snake and bee venoms following intraperitoneal and intracisternal injection." Toxicon (1984). 22:308-311
  3. Habermann, "Bee and wasp venoms: the biochemistry and pharmacology of their peptides and enzymes are reviewed." Science (1972). 177:314-322
 
Prices
Code
Quantity
US $
€uro
L8403
1 x 1 mg
68.60
49.00
5 x 1 mg
274.40
196.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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