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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L8403 MELITTIN
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an inhibitor of protein-kinases and cell membrane lytic factor from the venom of the Honeybee, Apis mellifera.
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26-amino acid peptide with no disulfide bridge, from Apis mellifera bee venom; the NH2 terminal part of the molecule is predominantly hydrophobic and the C terminal part is hydrophilic and strongly basic.
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| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 68.60 | 49.00 |
5 x 1 mg | 274.40 | 196.00 |
- Molecular Weight : 2,847 Da.
- Solubility in : well in water and saline.
- Purity min. : Percent by weight:
Melittin: 67 Peptidic contaminants: 9
Acetate: 9 H20: 15
Phospholipase max.: 0.01
Percent by mole:
Phospholipase max.: 0.002
- Biological Activity : inhibitor of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane), with an IC50 of 1-4 µM; cell membrane lytic factor.
- Toxicity (LD50) : mice (i.p.): 12 µg/g.
mice (intracisternal injection): 0.86 µg/g.
- Storage recommendations : store preferably at -20°C; solution for use: 100 µM; the solution can be freezed and thawed.
- CAS Reg. No. : 20449-79-0
- Bibliography :
- Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5):2753-2758
- Schweitz, "Lethal potency in mice of toxins from scorpion, sea anemone, snake and bee venoms following intraperitoneal and intracisternal injection." Toxicon (1984). 22:308-311
- Habermann, "Bee and wasp venoms: the biochemistry and pharmacology of their peptides and enzymes are reviewed." Science (1972). 177:314-322
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