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Home Page > Alphabetical Index > APAMIN

APAMIN Prod. No L8407 - CAS # 24345-16-2
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Product Name APAMIN
Product Code L8407
APAMIN

Molecular Formula
Description

a small‚ basic‚ polypeptidic toxin which blocks a class of Ca2+-activated K+ channels; crosses the blood brain barrier; possesses a convulsant activity.

18-amino acid peptide with 2 disulfide bridges‚ ‚ from Apis mellifera bee venom.

 
Biological Activity

nanomolar concentrations block small conductance Ca2+-activated K+ channels.
Induces motor hyperactivity and is a potent convulsant.

 
Chemical and Physical Properties
 
CAS No. 24345-16-2 Molecular Weight 2‚027 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 757 Melting point
PubChem SID Solubility well in water and saline.
Purity 95% (HPLC). Optical Activity
Toxicity (LD50) mice (i.v.): 3.8 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at -4°C.
Safety Recommendations
 
Bibliographic References
  1. Moczydlowski et al. "An emerging pharmacology of peptide toxins targeted against potassium channels." J. Membr. Biol. (1988). 105(2):95
  2. Bernardi et al. "Molecular properties of potassium channels." Arzneim.-Forsch./Drug Res. (1989). 39(1), 1a:159
  3. Merot et al. "Two types of K+ channels in the apical membrane of rabbit proximal tubule in primary culture." Biochim. Biophys. Acta (1989). 978:134
  4. Robertson et al. "Potassium channel modulators: Scientific applications and therapeutic promises." J. Med. Chem. (1990). 33(6):1529
 
Prices
Code
Quantity
US $
Euro (¤)
L8407-100UG
1 x 100 µg
49,00
35,00
5 x 100 µg
196,00
140,00
L8407-200UG
1 x 200 µg
85,40
61,00
5 x 200 µg
341,60
244,00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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