a small‚ basic‚ polypeptidic toxin which blocks a class of Ca²⁺-activated K⁺ channels; crosses the blood brain barrier; possesses a convulsant activity.

18-amino acid peptide with 2 disulfide bridges‚ ‚ from Apis mellifera bee venom.

nanomolar concentrations block small conductance Ca²⁺-activated K⁺ channels.
Induces motor hyperactivity and is a potent convulsant.

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4. Robertson et al. "Potassium channel modulators: Scientific applications and therapeutic promises." J. Med. Chem. (1990). 33(6):1529