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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L8407 APAMIN
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a small, basic, polypeptidic toxin which blocks a class of Ca2+-activated K+ channels; crosses the blood brain barrier; possesses a convulsant activity.
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18-amino acid peptide with 2 disulfide bridges, from Apis mellifera bee venom.
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| PRICES |
| Quantity | US Dollars | EURO |
200 µg | 54.60 | 39.00 |
5 x 200 µg | 218.40 | 156.00 |
- Molecular Weight : 2,027 Da.
- Solubility in : well in water and saline.
- Purity min. : 95% (HPLC).
- Biological Activity : nanomolar concentrations block small conductance Ca2+-activated K+ channels.
Induces motor hyperactivity and is a potent convulsant.
- Toxicity (LD50) : mice (i.v.): 3.8 mg/kg.
- Storage recommendations : Store at -4°C.
- CAS Reg. No. : 24345-16-2
- Merck Index 11th Ed. : 757
- Bibliography :
- Moczydlowski et al. "An emerging pharmacology of peptide toxins targeted against potassium channels." J. Membr. Biol. (1988). 105(2):95
- Bernardi et al. "Molecular properties of potassium channels." Arzneim.-Forsch./Drug Res. (1989). 39(1), 1a:159
- Merot et al. "Two types of K+ channels in the apical membrane of rabbit proximal tubule in primary culture." Biochim. Biophys. Acta (1989). 978:134
- Robertson et al. "Potassium channel modulators: Scientific applications and therapeutic promises." J. Med. Chem. (1990). 33(6):1529
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