the main antigen of bee venom, causing hydrolysis of erythrocytes and mast cells membrane phospholipids, and acting in synergy with Melittin.

Protein, from Apis mellifera bee venom.

• Molecular Weight : ~ 18,500 Da.
  
  
• Solubility in : soluble in water.
  
  
• Purity min. : 96 %. (HPLC, amino acid analysis)
  
  
• Biological Activity : activity > 850 units per mg protein at pH 8.9 at 25 °C., using egg yolk phosphatidylcholine.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 0.37 µg/g.
  
  
• Storage recommendations : stable in dried state; store at 4°C.
  
  
• CAS Reg. No. : 9001-84-7
  
  
• Bibliography :
  
  1. Hollander et al., "Characterization of the oligosaccharide structures on bee venom phospholipase A2." Carbohydrate Research (1993). 247:291-297
  2. Kubelka et al., "Primary structures of the N-linked carbohydrate chains from honeybee venom phospolipase A2." European Journal of Biochemistry (1993). 213(3):1193-1204
  3. Prenner et al., "The antigenicity of the carbohydrate moiety of an insect glycoprotein, honey-bee (Apis mellifera) venom phospholipase A2: the role of alpha 1,3-fucosylation of the asparagine-bound N-acetylglucosamine." Biochemical Jl (London 1984) (1992) 284(p.2):377-380
  4. Slotta et al., "Enzymatic and toxic activity of phospholipase A." in A. De Vries and E. Kochva, Eds., Toxins of Animal and Plant Origin, Vol. I, Gordon and Breach, New-York (1971), 401-418.