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Home Page > Alphabetical Index > CONOTOXIN MVII A (ω-)

CONOTOXIN MVII A (ω-) Prod. No L8501 - CAS #
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Product Name CONOTOXIN MVII A (ω-)
(Syn.: ω-CgTx MVII A)
Product Code L8501
CONOTOXIN MVII A (ω-)

Molecular Formula
Description

a N-type Ca2+ channel blocker.

25-aminoacid peptide with 3 disulfide bridges. ‚ synthetic‚ originally from Conus magus molluscan venom.

 
Biological Activity

ω-CgTx MVII A and ω-CgTx GVI A (from Conus geographus) are both neuronal Ca2+ channels blockers and appear to compete for the same sites in mammalian brain‚ but they seem to present some differences in their receptor binding characteristics; in particular the high affinity binding of ω-CgTx MVII A has narrower specificity in amphibian brain.

 
Chemical and Physical Properties
 
CAS No. Molecular Weight 2‚639.2 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity 97 % (HPLC). Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations Stable in freeze dried state. In solution‚ keep at -20°C.
Safety Recommendations
 
Bibliographic References
  1. Olivera et al., "Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using Omega-conotoxin from Conus magus venom." Biochemistry. (1987) 26:2086-2090
 
Prices
Code
Quantity
US $
Euro (¤)
L8501
1 x 100 µg
259,00
185,00
5 x 100 µg
1 036,00
740,00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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