ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS
L8501 wCONOTOXIN MVII A
( Omega-CgTx MVII A )
a N-type Ca2+ channel blocker.
25-aminoacid peptide with 3 disulfide bridges. Synthetic, originally from Conus magus molluscan venom.
PRICES
Quantity
US Dollars
EURO
100 µg
183.40
131.00
5 x 100 µg
733.60
524.00
Molecular Weight : 2,639.2 Da.
Solubility in : well in water and saline.
Purity min. : 97 % (HPLC).
Biological Activity : Omega-CgTx MVII A and Omega-CgTx GVI A (from Conus geographus) are both neuronal Ca2+ channels blockers and appear to compete for the same sites in mammalian brain, but they seem to present some differences in their receptor binding characteristics; in particular the high affinity binding of Omega-CgTx MVII A has narrower specificity in amphibian brain.
Storage recommendations : Stable in freeze dried state. In solution, keep at -20°C.
Bibliography :
Olivera et al., "Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using Omega-conotoxin from Conus magus venom." Biochemistry. (1987) 26:2086-2090