a N-type Ca²⁺ channel blocker.

25-aminoacid peptide with 3 disulfide bridges. Synthetic, originally from Conus magus molluscan venom.

• Molecular Weight : 2,639.2 Da.
  
  
• Solubility in : well in water and saline.
  
  
• Purity min. : 97 % (HPLC).
  
  
• Biological Activity : Omega-CgTx MVII A and Omega-CgTx GVI A (from Conus geographus) are both neuronal Ca²⁺ channels blockers and appear to compete for the same sites in mammalian brain, but they seem to present some differences in their receptor binding characteristics; in particular the high affinity binding of Omega-CgTx MVII A has narrower specificity in amphibian brain.
  
  
• Storage recommendations : Stable in freeze dried state. In solution, keep at -20°C.
  
  
• Bibliography :
  
  1. Olivera et al., "Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using Omega-conotoxin from Conus magus venom." Biochemistry. (1987) 26:2086-2090