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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L8503 TETRODOTOXIN
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| ( TTX ) |
| - citrate free - |
a highly specific Na+ channel blocker in excitable tissues.
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C11H17N3O8 from Fugu Fish organs.
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| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 120.40 | 86.00 |
5 x 1 mg | 481.60 | 344.00 |
10 x 1 mg | 782.60 | 559.00 |
- Molecular Weight : 319.28 Da.
- Melting Point : does not melt at 200 °C, darkens and turns black with increasing temperature.
- Solubility in : 2% acetic or citric acid, dilute sulfuric acid; slightly in water, dry alcohol and ether; insoluble in organic solvents.
- Purity min. : 96 %. (HPLC, IR, NMR)
- Physical Form : white crystal powder.
- Biological Activity : KD (cardiac myocytes in rats): 0.8 nM(2)
* 10-8 M block nervous system; * 10-5 M block heart muscle. The binding to Na + channel is reversible. ED50 = 3.7 nM.
- Toxicity (LD50) : mice (i.v.): 8.7 µg/kg.
mice (i.p.): 8 - 10 µg/kg.
mice (s.c.): 11.5 µg/kg.
- Storage recommendations : stable at room temperature, store preferably at 4°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity. Solution for use: reconstitute in citrate or acetate buffer, pH 4.8-4.9
Safety recommendations:
highly toxic.
- CAS Reg. No. : 4368-28-9
- RTECS No. : IO1450000
- Merck Index 11th Ed. : 9175
- Bibliography :
- Abraham et al. "Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade." J. Pharmacol. Exp. Ther. (1989). 251(3):1166
- Lombet et al. "A cardiac tetrodotoxin binding component: biochemical identification, characterization and properties." Biochemistry (1981). 20:1279-1285
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Revised : 26/04/2007 10:28 - Copyright © Latoxan |
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