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Home Page > Alphabetical Index > TETRODOTOXIN (citrate free)

TETRODOTOXIN (citrate free) Prod. No L8503 - CAS # 4368-28-9
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Product Name TETRODOTOXIN (citrate free)
(Syn.: TTX)
Product Code L8503
TETRODOTOXIN (citrate free)

C11H17N3O8
Molecular Formula C11H17N3O8
Description

a highly specific Na+ channel blocker in excitable tissues.

C11H17N3O8 ‚ from Fugu Fish organs.
 
Biological Activity

KD (cardiac myocytes in rats): 0.8 nM(2)

* 10-8 M block nervous system; * 10-5 M block heart muscle. The binding to Na
+ channel is reversible. ED50 = 3.7 nM.
 
Chemical and Physical Properties
 
CAS No. 4368-28-9 Molecular Weight 319.28 Da.
RTECS IO1450000 Physical Form white crystal powder.
Merck Index No (13th Ed.) 9175 Melting point does not melt at 200 °C‚ darkens and turns black with increasing temperature.
PubChem SID Solubility 2% acetic or citric acid‚ dilute sulfuric acid; slightly in water‚ dry alcohol and ether; insoluble in organic solvents.
Purity 96 %. (HPLC‚ IR‚ NMR) Optical Activity [a]D - 8.64° (c = 8.55 in dilute acetic acid)
Toxicity (LD50) mice (i.v.): 8.7 µg/kg.

mice (i.p.): 8 - 10 µg/kg.

mice (s.c.): 11.5 µg/kg.
Chemical Names
Storage & Reconstitution Recommendations stable at room temperature‚ store preferably at 4°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity. Solution for use: reconstitute in citrate or acetate buffer‚ pH 4.8-4.9

Safety recommendations:

highly toxic.
Safety Recommendations
 
Bibliographic References
  1. Abraham et al. "Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade." J. Pharmacol. Exp. Ther. (1989). 251(3):1166
  2. Lombet et al. "A cardiac tetrodotoxin binding component: biochemical identification, characterization and properties." Biochemistry (1981). 20:1279-1285
 
Prices
Code
Quantity
US $
€uro
L8503
1 x 1 mg
120.40
86.00
5 x 1 mg
481.60
344.00
10 x 1 mg
782.60
559.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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