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Home Page > Alphabetical Index > CONOTOXIN MVII C (ω-)

CONOTOXIN MVII C (ω-) Prod. No L8504 - CAS #
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Product Name CONOTOXIN MVII C (ω-)
Product Code L8504
CONOTOXIN MVII C (ω-)
Molecular Formula
Description

a blocker of w-conotoxin GVIA-insensitive Ca2+ channels‚ including P-type Ca2+-channels in cerebellar Purkinge cells.

26 amino acid peptide with 3 disulfide bridges. ‚ synthetic‚ originally from Conus magus molluscan venom
 
Biological Activity

ω-CgTx-MVIIC inhibits presynaptic Ca2+ channels‚ including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes‚ the P-type Ca2+ channels in cerebellar Purkinje cells‚ and a significant fraction of ω-CgTx-GVIA-resistant currents in hippocampal CA1 neurons.

ω-CgTx-MVIIC also presents an inhibition of ω-CgTx-GVIA-resistant depolarization-induced neurotransmetter release in cerebellar neurons of rats
 
Chemical and Physical Properties
 
CAS No. Molecular Weight 2756 Da.
RTECS Physical Form white powder.
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility water‚ saline.
Purity 99%. Reverse phase HPLC‚ capillary electrophoresis. Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state. In solution‚ keep at -20°C.
Safety Recommendations
 
Bibliographic References
  1. Hillyard et al., "A new Conus peptide ligand for mammalian presynaptic Ca2+ channels." Neuron (1992). 9:69-77
 
Prices
Code
Quantity
US $
€uro
L8504
1 x 100 µg
259.00
185.00
5 x 100 µg
1 036.00
740.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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