CONOTOXIN MVII C - LATOXAN Technical Data Sheet
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ION CHANNEL and RECEPTOR LIGANDS
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L8504 wCONOTOXIN MVII C

a blocker of w-conotoxin GVIA-insensitive Ca2+ channels, including P-type Ca2+-channels in cerebellar Purkinge cells.

26 amino acid peptide with 3 disulfide bridges. Synthetic, originally from Conus magus molluscan venom


PRICES
QuantityUS DollarsEURO
100 µg 191.80 137.00
5 x 100 µg 767.20 548.00


  • Molecular Weight : 2756 Da.

  • Solubility in : water, saline.

  • Purity min. : 99%. Reverse phase HPLC, capillary electrophoresis.

  • Physical Form : white powder.

  • Biological Activity : Omega-CgTx-MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of Omega-CgTx-GVIA-resistant currents in hippocampal CA1 neurons.
    Omega-CgTx-MVIIC also presents an inhibition of Omega-CgTx-GVIA-resistant depolarization-induced neurotransmetter release in cerebellar neurons of rats

  • Storage recommendations : stable in freeze-dried state. In solution, keep at -20°C.

  • Bibliography :
    1. Hillyard et al., "A new Conus peptide ligand for mammalian presynaptic Ca2+ channels." Neuron (1992). 9:69-77



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan