a blocker of w-conotoxin GVIA-insensitive Ca2+ channels, including P-type Ca2+-channels in cerebellar Purkinge cells.

26 amino acid peptide with 3 disulfide bridges. Synthetic, originally from Conus magus molluscan venom

• Molecular Weight : 2756 Da.
  
  
• Solubility in : water, saline.
  
  
• Purity min. : 99%. Reverse phase HPLC, capillary electrophoresis.
  
  
• Physical Form : white powder.
  
  
• Biological Activity : Omega-CgTx-MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of Omega-CgTx-GVIA-resistant currents in hippocampal CA1 neurons.
  Omega-CgTx-MVIIC also presents an inhibition of Omega-CgTx-GVIA-resistant depolarization-induced neurotransmetter release in cerebellar neurons of rats
  
  
• Storage recommendations : stable in freeze-dried state. In solution, keep at -20°C.
  
  
• Bibliography :
  
  1. Hillyard et al., "A new Conus peptide ligand for mammalian presynaptic Ca2⁺ channels." Neuron (1992). 9:69-77