Latoxan

Print this Print this page

LATOXAN
20 Rue Léon Blum
26000 Valence - France

Venoms - Toxins - Alkaloids - Plant Compounds - Ion Channel & Receptor Ligands

Google Custom Search
 Phone : (+33) 47 541 9191
Fax : (+33) 47 541 9199
Email : contact@latoxan.com
Contact Us

Home Page > Alphabetical Index > CONOTOXIN MVII C (ω-)

CONOTOXIN MVII C (ω-) Prod. No L8504 - CAS #
< First < Previous - Next > Last >

Product Name CONOTOXIN MVII C (ω-)
Product Code L8504
CONOTOXIN MVII C (ω-)
Molecular Formula
Description

a blocker of w-conotoxin GVIA-insensitive Ca2+ channels‚ including P-type Ca2+-channels in cerebellar Purkinge cells.

26 amino acid peptide with 3 disulfide bridges. ‚ synthetic‚ originally from Conus magus molluscan venom
 
Biological Activity

ω-CgTx-MVIIC inhibits presynaptic Ca2+ channels‚ including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes‚ the P-type Ca2+ channels in cerebellar Purkinje cells‚ and a significant fraction of ω-CgTx-GVIA-resistant currents in hippocampal CA1 neurons.

ω-CgTx-MVIIC also presents an inhibition of ω-CgTx-GVIA-resistant depolarization-induced neurotransmetter release in cerebellar neurons of rats
 
Chemical and Physical Properties
 
CAS No. Molecular Weight 2756 Da.
RTECS Physical Form white powder.
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility water‚ saline.
Purity 99%. Reverse phase HPLC‚ capillary electrophoresis. Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state. In solution‚ keep at -20°C.
Safety Recommendations
 
Bibliographic References
  1. Hillyard et al., "A new Conus peptide ligand for mammalian presynaptic Ca2+ channels." Neuron (1992). 9:69-77
 
Prices
Code
Quantity
US $
€uro
L8504
1 x 100 µg
191.80
137.00
5 x 100 µg
767.20
548.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

[ Ordering Information ] - [ Privacy Statement ] - [ Infos Légales ] - [ Contact Us ]

© Copyright of Latoxan SAS 2008 - France.
For Research Pharmaceutical and Medical Purposes Only.
DOCUMENT URL : http://www.latoxan.com/PHP/00000172.php
ModelBtx.html - Last Update 14/08/2009 11:47:04