a potent non-competitive GABA antagonist; convulsant; laboratory insecticide.

Organofluorate compound C₁₁H₆F₆N₂Cl₂, synthetic.

• Molecular Weight : 351 Da.
  
  
• Melting Point : 122-126 °C.
  
  
• Solubility in : soluble in alcohol, alcohol + water and acetone.
  
  
• Purity min. : 95 % (NMR).
  
  
• Biological Activity : (IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes:10 nM. inhibition of the GABA-dependent Cl- current: 5.3 nM;
  experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Cloflubicyne up to 10 µM.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 0.1 mg/kg.
  rat (orally): 0.2 mg/kg.
  
  
• Storage recommendations : store at room temperature.
  1 mg Cloflubicyne can be dissolved in 1 ml ethanol (up to 50 °C), then diluted in distilled water. Solution for experiments must contain less than 0.5 % ethanol and be stored at 0 °C.
  
  
• CAS Reg. No. : 224790-70-9
  
  
• Bibliography :
  
  1. Middelton et al., J. Fluor. Chem.(1982) 20:397-418
  2. Fetisov et al., J. Fluor. Chem.(1991) 54:301