a voltage-dependent and GABA-gated Cl- channels blocker; non-competitive GABA antagonist.

Organophosphorous compound C₅H₉O₄P, synthetic.

• Molecular Weight : 164 Da.
  
  
• Melting Point : 249-250 °C.
  
  
• Solubility in : well in alcohol and water.
  
  
• Purity min. : 95 % (NMR).
  
  
• Biological Activity : Cl- channel blocking concentration: IC₁₀₀ = 500 nM (Lymnaea stagnalis);
  experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Mebicyphat up to 10 µM.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 32.0 mg/kg. mice (i.v.): 30.5 mg/kg.
  
  
• Storage recommendations : store at room temperature.
  
  
• CAS Reg. No. : 1449-89-4
  
  
• Bibliography :
  
  1. Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136
  2. Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212
  3. V. I. Fetisov et al., Biol. Membr.(1986) (Russian). 3(5):968-970
  4. Squires R. F. et al., Mol. Pharmacol. (1983). 23:326-331