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Home Page > Alphabetical Index > MEBICYPHAT

MEBICYPHAT Prod. No L9003 - CAS # 1449-89-4
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Product Name MEBICYPHAT
Product Code L9003
MEBICYPHAT

C5H9O4P
Molecular Formula C5H9O4P
Description

a voltage-dependent and GABA-gated Cl- channels blocker; non-competitive GABA antagonist.

Organophosphorous compound C5H9O4P ‚ synthetic.
 
Biological Activity

Cl- channel blocking concentration: IC100 = 500 nM (Lymnaea stagnalis);

experiments with [3H]-labelled GABA-competitive ligands (Muscimol‚ Flunitrazepam) showed no influence of Mebicyphat up to 10 µM.
 
Chemical and Physical Properties
 
CAS No. 1449-89-4 Molecular Weight 164 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 249-250 °C.
PubChem SID Solubility well in alcohol and water.
Purity 95 % (NMR). Optical Activity
Toxicity (LD50) mice (i.p.): 32.0 mg/kg.
mice (i.v.): 30.5 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations store at room temperature.
Safety Recommendations
 
Bibliographic References
  1. Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136
  2. Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212
  3. V. I. Fetisov et al., Biol. Membr.(1986) (Russian). 3(5):968-970
  4. Squires R. F. et al., Mol. Pharmacol. (1983). 23:326-331
 
Prices
Code
Quantity
US $
€uro
L9003
1 x 1 mg
102.20
73.00
5 x 1 mg
408.80
292.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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