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Home Page > Alphabetical Index > ETBICYPHAT

ETBICYPHAT Prod. No L9004 - CAS # 1005-93-2
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Product Name ETBICYPHAT
Product Code L9004
ETBICYPHAT

C6H11O4P
Molecular Formula C6H11O4P
Description

a neuronal voltage-dependent and GABA-gated Cl- channels blocker; non-competitive GABA antagonist; causes epileptoform seizures.

Organophosphorous compound C6H11O4P ‚ synthetic.
 
Biological Activity

Cl- channel total blocking concentration: IC100 ~ 50 nM (Lymnaea stagnalis);
(IC50) for [3H]-dihydropicrotoxin binding with rat brain membrane P2 fraction: 5.0 µM (Ticku M.);

(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with human brain membranes : 5.9 µM (Casida J.);

experiments with [3H]-labelled GABA-competitive ligands (Muscimol‚ Funitrazepam) showed no influence of Etbicyphat up to 10 µM.
 
Chemical and Physical Properties
 
CAS No. 1005-93-2 Molecular Weight 178 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 201-202 °C.
PubChem SID Solubility well in alcohol and water.
Purity 95 % (NMR). Optical Activity
Toxicity (LD50) mice (i.p.): 1.0 mg/kg.

mice (i.v.): 0.35 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations store at room temperature.
Safety Recommendations
 
Bibliographic References
  1. Bellet et al., Science.(1973) 182:1135-1136
  2. Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212
  3. Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970
  4. Squires et al., Mol. Pharmacol.(1983) 23:326-331
 
Prices
Code
Quantity
US $
€uro
L9004
1 x 1 mg
186.20
133.00
5 x 1 mg
744.80
532.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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