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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L9004 ETBICYPHAT
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| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 186.20 | 133.00 |
5 x 1 mg | 744.80 | 532.00 |
- Molecular Weight : 178 Da.
- Melting Point : 201-202 °C.
- Solubility in : well in alcohol and water.
- Purity min. : 95 % (NMR).
- Biological Activity : Cl- channel total blocking concentration: IC100 ~ 50 nM (Lymnaea stagnalis);
(IC50) for [3H]-dihydropicrotoxin binding with rat brain membrane P2 fraction: 5.0 µM (Ticku M.);
(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with human brain membranes : 5.9 µM (Casida J.);
experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Funitrazepam) showed no influence of Etbicyphat up to 10 µM.
- Toxicity (LD50) : mice (i.p.): 1.0 mg/kg.
mice (i.v.): 0.35 mg/kg.
- Storage recommendations : store at room temperature.
- CAS Reg. No. : 1005-93-2
- Bibliography :
- Bellet et al., Science.(1973) 182:1135-1136
- Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212
- Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970
- Squires et al., Mol. Pharmacol.(1983) 23:326-331
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