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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L9005 PROPYBICYPHAT
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| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 138.60 | 99.00 |
5 x 1 mg | 554.40 | 396.00 |
- Molecular Weight : 192 Da.
- Melting Point : 234-236 °C.
- Solubility in : well in alcohol and water.
- Purity min. : 95 % (NMR).
- Biological Activity : (IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.5 nM;
inhibition of the GABA-dependent Cl- current at 1.09 nM;
(IC50) for [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 µM (Ticku M.);
(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with the human brain membranes: 1.1 µM (Casida J.);
experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Propybicyphat up to 10 µM.
- Toxicity (LD50) : mice (i.p.): 0.38 mg/kg.
- Storage recommendations : store at room temperature
- CAS Reg. No. : 51486-74-9
- Bibliography :
- Bellet et al., Science.(1973) 182:1135-1136
- Squires et al., Mol. Pharmacol.(1983) 23:326-336
- Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970
- Cooper et al., Mol. Pharmacol. (1983). 23:207-212
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