Latoxan

Print this Print this page

LATOXAN
20 Rue Léon Blum
26000 Valence - France

Venoms - Toxins - Alkaloids - Plant Compounds - Ion Channel & Receptor Ligands

Google Custom Search
 Phone : (+33) 47 541 9191
Fax : (+33) 47 541 9199
Email : contact@latoxan.com
Contact Us

Home Page > Alphabetical Index > PROPYBICYPHAT

PROPYBICYPHAT Prod. No L9005 - CAS # 51486-74-9
< First < Previous - Next > Last >

Product Name PROPYBICYPHAT
Product Code L9005
PROPYBICYPHAT

C7H13O4P
Molecular Formula C7H13O4P
Description

a GABA-gated chloride channel blocker‚ non-competitive GABA antagonist in mammals.

Organophosphorous compound‚ C7H13O4P ‚ synthetic.
 
Biological Activity

(IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.5 nM;

inhibition of the GABA-dependent Cl- current at 1.09 nM;

(IC50) for [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 µM (Ticku M.);

(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with the human brain membranes: 1.1 µM (Casida J.);

experiments with [3H]-labelled GABA-competitive ligands (Muscimol‚ Flunitrazepam) showed no influence of Propybicyphat up to 10 µM.
 
Chemical and Physical Properties
 
CAS No. 51486-74-9 Molecular Weight 192 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 234-236 °C.
PubChem SID Solubility well in alcohol and water.
Purity 95 % (NMR). Optical Activity
Toxicity (LD50) mice (i.p.): 0.38 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations store at room temperature
Safety Recommendations
 
Bibliographic References
  1. Bellet et al., Science.(1973) 182:1135-1136
  2. Squires et al., Mol. Pharmacol.(1983) 23:326-336
  3. Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970
  4. Cooper et al., Mol. Pharmacol. (1983). 23:207-212
 
Prices
Code
Quantity
US $
€uro
L9005
1 x 1 mg
138.60
99.00
5 x 1 mg
554.40
396.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

[ Ordering Information ] - [ Privacy Statement ] - [ Infos Légales ] - [ Contact Us ]

© Copyright of Latoxan SAS 2008 - France.
For Research Pharmaceutical and Medical Purposes Only.
DOCUMENT URL : http://www.latoxan.com/PHP/00000192.php
ModelBtx.html - Last Update 14/08/2009 11:48:34