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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L9006 ISOBICYPHAT
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| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 158.20 | 113.00 |
5 x 1 mg | 632.80 | 452.00 |
- Molecular Weight : 192 Da.
- Melting Point : 222-223 °C
- Solubility in : well in alcohol and water.
- Purity min. : 95 % (NMR).
- Biological Activity : (IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.2 nM.
(IC50) for the inhibition of [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 µM; (Ticku M.);
(IC50) for the inhibition of [35S]-tert.butyl-thionebicyclophosphate binding with human brain membranes: 480 nM. (Casida J.E.);
experiments with [3H]-labeled GABA-competitive ligands (muscimol, flunitrazepam) showed no influence of Isobicyphat up to 10 µM.
- Toxicity (LD50) : mice (i.p.): 0.18 mg/kg.
mice (i.v.): 0.31 mg/kg.
- Storage recommendations : store at room temperature.
- CAS Reg. No. : 51052-72-3
- Bibliography :
- Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136
- Cooper et al., Mol. Pharmacol. (1983). 23:207-212
- V. I. Fetisov et al., Biol. Membr.(1986) (Russian). 3(5):968-970
- Squires et al., Mol. Pharmacol.(1983) 23:326-331
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Revised : 26/04/2007 10:27 - Copyright © Latoxan |
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