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Home Page > Alphabetical Index > ISOBICYPHAT

ISOBICYPHAT Prod. No L9006 - CAS # 51052-72-3
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Product Name ISOBICYPHAT
Product Code L9006
ISOBICYPHAT

C7H13O4P
Molecular Formula C7H13O4P
Description

a non-competitive GABA antagonist; potent convulsant: causes epileptoform seizures.

Organophosphorous compound‚ C7H13O4P ‚ synthetic.
 
Biological Activity

(IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.2 nM.

(IC50) for the inhibition of [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 µM; (Ticku M.);

(IC50) for the inhibition of [35S]-tert.butyl-thionebicyclophosphate binding with human brain membranes: 480 nM. (Casida J.E.);

experiments with [3H]-labeled GABA-competitive ligands (muscimol‚ flunitrazepam) showed no influence of Isobicyphat up to 10 µM.
 
Chemical and Physical Properties
 
CAS No. 51052-72-3 Molecular Weight 192 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 222-223 °C
PubChem SID Solubility well in alcohol and water.
Purity 95 % (NMR). Optical Activity
Toxicity (LD50) mice (i.p.): 0.18 mg/kg.

mice (i.v.): 0.31 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations store at room temperature.
Safety Recommendations
 
Bibliographic References
  1. Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136
  2. Cooper et al., Mol. Pharmacol. (1983). 23:207-212
  3. V. I. Fetisov et al., Biol. Membr.(1986) (Russian). 3(5):968-970
  4. Squires et al., Mol. Pharmacol.(1983) 23:326-331
 
Prices
Code
Quantity
US $
€uro
L9006
1 x 1 mg
158.20
113.00
5 x 1 mg
632.80
452.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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