a potent non-competitive GABA antagonist in mammals; causes epileptoform seizures.

Organophosphorous compound, C₆H₁₁O₃PS, synthetic.

• Molecular Weight : 194.19 Da.
  
  
• Melting Point : 179 °C.
  
  
• Solubility in : soluble in ethanol and ethanol + water.
  
  
• Purity min. : 98 % (NMR).
  
  
• Biological Activity : IC₅₀ for GABA-dependent [36Cl] uptake blockade in rat brain synaptosomes: 0.2 nM;
  IC₅₀ for [35S]-tert.butyl-thionebicyclophosphate binding (Housefly brain membranes): 3.2 µM.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 1.1 mg/kg.
  
  
• Storage recommendations : Store at room temperature; solution for use: 1 mg/ml in ethanol (dilution is then possible in an equal volume of water).
  
  
• CAS Reg. No. : 224790-71-0
  
  
• Bibliography :
  
  1. Wadswort et al., J. Am. Chem. Soc. (1962) 84(2):610
  2. Squires et al., Mol. Pharmacol.(1983) 23:326-331
  3. Cohen et al., Pest. Biochem. Physiol.(1986) 25(1):63