ETBICYTHIONAT - LATOXAN Technical Data Sheet
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ION CHANNEL and RECEPTOR LIGANDS
TOXINS & ALKALOIDS

 
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L9015 ETBICYTHIONAT

a potent non-competitive GABA antagonist in mammals; causes epileptoform seizures.

  1. see annexed table : Compared Activities of some Cl- Channel Blockers....

Organophosphorous compound, C6H11O3PS, synthetic.


PRICES
QuantityUS DollarsEURO
100 µg 159.60 114.00
5 x 100 µg 638.40 456.00


  • Molecular Weight : 194.19 Da.

  • Melting Point : 179 °C.

  • Solubility in : soluble in ethanol and ethanol + water.

  • Purity min. : 98 % (NMR).

  • Biological Activity : IC50 for GABA-dependent [36Cl] uptake blockade in rat brain synaptosomes: 0.2 nM;
    IC50 for [35S]-tert.butyl-thionebicyclophosphate binding (Housefly brain membranes): 3.2 µM.

  • Toxicity (LD50) : mice (i.p.): 1.1 mg/kg.

  • Storage recommendations : Store at room temperature; solution for use: 1 mg/ml in ethanol (dilution is then possible in an equal volume of water).

  • CAS Reg. No. : 224790-71-0

  • Bibliography :
    1. Wadswort et al., J. Am. Chem. Soc. (1962) 84(2):610
    2. Squires et al., Mol. Pharmacol.(1983) 23:326-331
    3. Cohen et al., Pest. Biochem. Physiol.(1986) 25(1):63



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan