GABAA-gated Cl- channels blocker; non-competitive GABAA antagonist.

Sulfur-nitrogen heterocycle heteroadamantane, C₄H₈N₄O₄S₂, synthetic.

• Molecular Weight : 240.26 Da (NMR).
  
  
• Melting Point : > 270 °C.
  
  
• Solubility in : water and DMSO; moderately in acetone; insoluble in methanol and ethanol.
  
  
• Purity min. : 97 %.
  
  
• Biological Activity : IC₅₀ for GABAA-dependent [36Cl]-uptake blockade: 0.5 µM (mouse brain).
  
  
• Toxicity (LD₅₀) : mice (i.p.): 0.24 mg/kg.
  
  
• Storage recommendations : store at room temperature.
  
  
• CAS Reg. No. : 199488-98-7
  
  
• Merck Index 11th Ed. : 9158
  
  
• Bibliography :
  
  1. Esser et al. Chem. Res. Toxicol.(1991) 4(2):162
  2. Casida et al., Toxicol. Appl. Pharmacol. (1976). 36:261