a highly selective M₁ Muscarinic receptor antagonist.

Quaternary ammonium salt, C₁₆H₂₀NS₂I, synthetic.

• Molecular Weight : 417.37 Da.
  
  
• Melting Point : 216-218 °C.
  
  
• Solubility in : water (heat up), ethanol.
  
  
• Purity min. : 95 % (NMR).
  
  
• Biological Activity : pIC₅₀ (= -log IC₅₀):M₁ (rat brain) = 8.46
  M₂ (heart) = 5.10
  selectivity: [IC₅₀]M₂ / [IC₅₀]M₁= 2291
  data determined by [³H]-QNB binding method, Pirenzepine as standard (unpublished).
  
  
• Storage recommendations : Store at +4°C, in dark place. Solution for use: 10-3 M.
  
  
• CAS Reg. No. : 36944-86-2
  
  
• Bibliography :
  
  1. V. Malyguin et al.; XIII int. symp. Med. Chem. (Paris : 19-24 sept.); Abstr.; 312 (1994).