a Muscarinic receptors antagonist.

Ammonium salt, quinuclidine derivative, C₂₀H₂₁N.HCl synthetic.

• Molecular Weight : 311.85 Da.
  
  
• Melting Point : 261-263°C
  
  
• Solubility in : water + ethanol; water (heat up).
  
  
• Purity min. : min. 98 % (TLC, NMR).
  
  
• Biological Activity : pIC₅₀ (= -log IC₅₀): M₁ (rat brain) = 7.12
  M₂ (heart) = 6.43
  selectivity:[IC₅₀]_M2 / [IC₅₀]_M1 = 4.89
  determined by [³H]-QNB binding method, Pirenzepine as standard (unpublished).
  
  
• Toxicity (LD₅₀) : mice (orally): 106 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place. Solution for use: 10^-3 M.
  
  
• CAS Reg. No. : 60697-89-4
  
  
• Bibliography :
  
  1. Michlina et al., Chim. Heterocycl. Soed. (1976) (Russian). 7:935