Rigid bicyclic analog of TMA and TEA. Molecular probe for calibration of the size of ion channels or receptors sites. Nicotinic AChR blocker. Acetylcholinesterase inhibitor. Lipid layers modifier.

Quaternary quinuclidine derivative, C₉H₁₈BrN, synthetic.

• Molecular Weight : 220.15 Da.
  
  
• Melting Point : 276-278 °C.
  
  
• Solubility in : water, ethanol.
  
  
• Purity min. : min. 98%. (NMR (D2O))
  
  
• Physical Form : colorless crystal powder
  
  
• Chemical Name : 1-ethyl quinicludinium bromide, N-ethyl quinuclidinium bromide.
  
  
• Biological Activity : Nicotinic AChR : less active than Tetraethylammonium (TEA) and Tetramethylammonium (TMA) .
  Acetylcholinesterase: TMA Ki =1.87 mM; TEA Ki =1.04 mM; QEt Ki =6.5 mM [2].
  
  
• Toxicity (LD₅₀) : mice (orally): 450 mg/kg
  
  
• Storage recommendations : store at room temperature in a dark place, in a dessicator (extremely hygroscopic). Solution for use: dissolve in water: 10-3M (2 mg in 9.09 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : Do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 45732-65-8
  
  
• Bibliography :
  
  1. Kellet et al., J. Pharm. Sci. (1966). 55(3):414-417
  2. Barlow, Molec. Pharm. (1971). 7(4):357