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Home Page > Alphabetical Index > Q° Me

Q° Me Prod. No L9035 - CAS # 45651-41-0
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Product Name Q° Me
Product Code L9035
Q° Me

C8H16IN
Molecular Formula C8H16IN
Description

a rigid bicyclic analog of TMA and TEA. Molecular probe for calibration of the size of ion channels or receptors sites. Nicotinic AChR blocker. Acetylcholinesterase inhibitor. Lipid layers modifier.

Quaternary quinuclidine derivative‚ C8H16IN ‚ synthetic.
 
Biological Activity

Nicotinic AChR: less active than Tetraethylammonium (TEA) and Tetramethylammonium (TMA).

Acetylcholinesterase: Ki TMA=1.87 mM‚ Ki TEA=1.04 mM‚ Ki QMe=0.12 mM [2].
 
Chemical and Physical Properties
 
CAS No. 45651-41-0 Molecular Weight 253.13 Da.
RTECS Physical Form yellowish crystal powder.
Merck Index No (13th Ed.) Melting point > 269-273 °C.
PubChem SID Solubility very soluble in water‚ ethanol.
Purity min. 98%. (NMR (D2O)) Optical Activity
Toxicity (LD50) mice (orally): 200 mg/kg
Chemical Names 1-methyl quinicludinium iodide‚ N-methyl quinuclidinium iodide.
Storage & Reconstitution Recommendations store at room temperature in a dark place‚ in a dessicator (extremely hygroscopic). Solution for use: dissolve in water: 10-3M (2 mg in 7.91 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations Do not swallow or inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Lukec R. et al., Chem. Listy (1955). 49: 510-508
  2. Kellet Jr., J. Pharm. Sci. (1965). 54 (3): 883-887
  3. Kellet Jr., J. Pharm. Sci. (1966). 55 (3): 414-417
 
Prices
Code
Quantity
US $
€uro
L9035
1 x 2 mg
96.60
69.00
5 x 2 mg
386.40
276.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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