a rigid bicyclic analog of TMA and TEA. Molecular probe for calibration of the size of ion channels or receptors sites. Nicotinic AChR blocker. Acetylcholinesterase inhibitor. Lipid layers modifier.

Quaternary quinuclidine derivative, C₈H₁₆IN, synthetic.

• Molecular Weight : 253.13 Da.
  
  
• Melting Point : > 269-273 °C.
  
  
• Solubility in : very soluble in water, ethanol.
  
  
• Purity min. : min. 98%. (NMR (D2O))
  
  
• Physical Form : yellowish crystal powder.
  
  
• Chemical Name : 1-methyl quinicludinium iodide, N-methyl quinuclidinium iodide.
  
  
• Biological Activity : Nicotinic AChR: less active than Tetraethylammonium (TEA) and Tetramethylammonium (TMA).
  Acetylcholinesterase: Ki TMA=1.87 mM, Ki TEA=1.04 mM, Ki QMe=0.12 mM [2].
  
  
• Toxicity (LD₅₀) : mice (orally): 200 mg/kg
  
  
• Storage recommendations : store at room temperature in a dark place, in a dessicator (extremely hygroscopic). Solution for use: dissolve in water: 10^-3M (2 mg in 7.91 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : Do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 45651-41-0
  
  
• Bibliography :
  
  1. Lukec R. et al., Chem. Listy (1955). 49: 510-508
  2. Kellet Jr., J. Pharm. Sci. (1965). 54 (3): 883-887
  3. Kellet Jr., J. Pharm. Sci. (1966). 55 (3): 414-417