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Home Page > Alphabetical Index > QUIRESTON-A

QUIRESTON-A Prod. No L9037 - CAS #
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Product Name QUIRESTON-A
(Syn.: NAQ=O)
Product Code L9037
QUIRESTON-A

C10H16BrNO
Molecular Formula C10H16BrNO
Description

an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; acetylcholine synthesis inhibitor; weak penetration of biological membranes.

Quinicludine derivative C10H16BrNO

 
Biological Activity

Cell impermeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table.

poor penetration of biological membranes.
 
Chemical and Physical Properties
 
CAS No. Molecular Weight 246.14 Da.
RTECS Physical Form slightly yellowish crystal powder
Merck Index No (13th Ed.) Melting point 166-168 °C
PubChem SID Solubility water‚ ethanol and DMSO.
Purity min. 99.5%. (NMR (D2O)) Optical Activity
Toxicity (LD50) mice (orally) 500 mg/kg
Chemical Names 1-allyl 3-quinicludon bromide; N-allyl-3-oxoquinuclidinium bromide.
Storage & Reconstitution Recommendations Store in a dark place in a dessicator; solutions are stable for 1-2 days at room temperature. Solution for use: 10-3M (2 mg in 8.13 ml).
Safety Recommendations
 
Bibliographic References
  1. Dahlbom R. et al., "Cell Mol. Basis Cholinergic Funct.", Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354
  2. Sterling et al., "Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives", J. Neurochem.(1986). 46(14):1170-1175
  3. Doukas P.H. et al., ibid, 355-360
  4. Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416
  5. Tamaru M. et al., Brain Res (1988). 473(2):205-226
  6. Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359
 
Prices
Code
Quantity
US $
€uro
L9037
1 x 2 mg
74.20
53.00
5 x 2 mg
296.80
212.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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