PENETRAN Cl - LATOXAN Technical Data Sheet
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L9038 PENETRAN Cl

an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; acetylcholine synthesis inhibitor; good penetration of biological membranes.

Quinicludine derivative, C14H14NOCl .HCl, synthetic.


PRICES
QuantityUS DollarsEURO
2 mg 96.60 69.00
5 x 2 mg 386.40 276.00


  • Molecular Weight : 284.18 Da.

  • Melting Point : 185-187 °C.

  • Solubility in : water, ethanol and DMSO.

  • Purity min. : min. 99.5%.
    TLC [Silufol UV-254, MeOH:NH3(25%) Rf =0.68, development in UV light followed with Dragendorff¨ reagent]; NMR (D2O).

  • Physical Form : slightly yellowish crystal powder.

  • Chemical Name : Z-2-((3'chlorophenyl)methylene]-3-quinuclidon HCl;
    Z-2-[(3'-chlorophenyl)methylene]-3-oxoquinuclidine HCl

  • Biological Activity : Cell permeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table.
    good penetration of biological membranes.

  • Toxicity (LD50) : mice (orally) >700 mg/kg

  • Storage recommendations : Store in a dark place in a dessicator; solutions are stable for 1-2 days at room temperature. Solution for use: 10-3 M (2 mg in 8.06 ml).

  • Bibliography :
    1. Dahlbom R. et al., "Cell Mol. Basis Cholinergic Funct.", Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354
    2. Sterling et al., "Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives", J. Neurochem.(1986). 46(14):1170-1175
    3. Doukas P.H. et al., ibid, 355-360
    4. Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416
    5. Tamaru M. et al., Brain Res (1988). 473(2):205-226
    6. Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan