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Home Page > Alphabetical Index > PENETRAN Cl

PENETRAN Cl Prod. No L9038 - CAS #
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Product Name PENETRAN Cl
Product Code L9038
PENETRAN Cl

C14H14NOCl .HCl synthetic.
Molecular Formula C14H14NOCl .HCl synthetic.
Description

an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; acetylcholine synthesis inhibitor; good penetration of biological membranes.

Quinicludine derivative‚ C14H14NOCl .HCl synthetic.

 
Biological Activity

Cell permeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table.

good penetration of biological membranes.
 
Chemical and Physical Properties
 
CAS No. Molecular Weight 284.18 Da.
RTECS Physical Form slightly yellowish crystal powder.
Merck Index No (13th Ed.) Melting point 185-187 °C.
PubChem SID Solubility water‚ ethanol and DMSO.
Purity min. 99.5%.
TLC [Silufol UV-254‚ MeOH:NH3(25%) Rf =0.68‚ development in UV light followed with Dragendorff¨ reagent]; NMR (D2O).		 Optical Activity
Toxicity (LD50) mice (orally) >700 mg/kg
Chemical Names Z-2-((3'chlorophenyl)methylene]-3-quinuclidon HCl;

Z-2-[(3'-chlorophenyl)methylene]-3-oxoquinuclidine HCl
Storage & Reconstitution Recommendations Store in a dark place in a dessicator; solutions are stable for 1-2 days at room temperature. Solution for use: 10-3 M (2 mg in 8.06 ml).
Safety Recommendations
 
Bibliographic References
  1. Dahlbom R. et al., "Cell Mol. Basis Cholinergic Funct.", Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354
  2. Sterling et al., "Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives", J. Neurochem.(1986). 46(14):1170-1175
  3. Doukas P.H. et al., ibid, 355-360
  4. Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416
  5. Tamaru M. et al., Brain Res (1988). 473(2):205-226
  6. Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359
 
Prices
Code
Quantity
US $
€uro
L9038
1 x 2 mg
96.60
69.00
5 x 2 mg
386.40
276.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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