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Home Page > Alphabetical Index > QUIRESTON

QUIRESTON Prod. No L9039 - CAS # 6659-51-4
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Product Name QUIRESTON
Product Code L9039
QUIRESTON

C8H14INO
Molecular Formula C8H14INO
Description

a potent inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; acetylcholine synthesis inhibitor; weak penetration of biological membranes.

Quinicludine derivative‚ C8H14INO ‚ synthetic.
 
Biological Activity

cell impermeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table.

poor penetration of biological membranes.
 
Chemical and Physical Properties
 
CAS No. 6659-51-4 Molecular Weight 267.10 Da.
RTECS Physical Form slightly yellowish crystal powder.
Merck Index No (13th Ed.) Melting point 275-277 °C.
PubChem SID Solubility water‚ ethanol and DMSO.
Purity min. 99.5%. (NMR (D2O)). Optical Activity
Toxicity (LD50) mice (orally) >500 mg/kg
Chemical Names 3-quinuclidon methoiodide; 1-methyl-3-oxoquinuclidium iodide.
Storage & Reconstitution Recommendations store in a dark place in a dessicator; solutions are stable for 1-2 days at room temperature. Solution for use: 10-3M (2 mg in 7.49 ml).
Safety Recommendations
 
Bibliographic References
  1. Dahlbom R. et al., "Cell Mol. Basis Cholinergic Funct.", Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354
  2. Sterling et al., "Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives", J. Neurochem.(1986). 46(14):1170-1175
  3. Doukas P.H. et al., ibid, 355-1175
  4. Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416
  5. Tamaru M. et al., Brain Res (1988). 473(2):205-226
  6. Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359
 
Prices
Code
Quantity
US $
€uro
L9039
1 x 2 mg
74.20
53.00
5 x 2 mg
296.80
212.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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