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Home Page > Alphabetical Index > PEMPIDINE TARTRATE

PEMPIDINE TARTRATE Prod. No L9043 - CAS # 546-48-5
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Product Name PEMPIDINE TARTRATE
(Syn.: Pirilene‚ PMP)
Product Code L9043
PEMPIDINE TARTRATE

C10H21N .C4H6O6
Molecular Formula C10H21N .C4H6O6
Description

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Antihypertensive. Good penetration of biological membranes. Monocyclic analog of TEMECHINE.

Piperidine derivative‚ C10H21N .C4H6O6 ‚ synthetic.
 
Biological Activity

For comparative information see the attached tables.
Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.


Produces a slowly developing voltage-dependent block of ionoforetically activated cholinergic currents of the lobster gastric mill [3‚ 4].


CNS activity: see the attached table.


35 mg/kg increases ATP and decreases AMP [5]. Modulation of Dopamine release [6]. Increases IP level (Sherman).
 
Chemical and Physical Properties
 
CAS No. 546-48-5 Molecular Weight 305.37 Da.
RTECS Physical Form colorless crystal powder
Merck Index No (13th Ed.) 7022 Melting point 150-151°C
PubChem SID Solubility water‚ ethanol.
Purity min. 98%.

TLC (Silufol UV-254‚ MeOH:NH3(25%) Rf 0.78‚ development with Dragendorff¨ reagent); NMR (D2O).		 Optical Activity
Toxicity (LD50) mice (orally): 275 mg/kg
Chemical Names 1‚2‚2‚6‚6-pentamethylpiperidine d-tartrate.
Storage & Reconstitution Recommendations store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 6.56 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations Do not swallow or inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Lee J.E. et al., Nature (1958) 181:1717
  2. Romano C. et al, Psychopharmacologie (1981) 74(4):310-315
  3. Mader et al., "Voltage dependent blocade of a crustacean muscle", J. Exp. Biol. (1980). 88:147-159
  4. Lingle, J. Physio. (1983) (London). 339:419-437
  5. Tichonenko V.M., Farm.Toxikol.(Kiev) (1980). (13):109-125 (1978); [p.42-44 Engl.]., CA 93: 762
  6. Rapier C. et al., Neuropharm. (1990). 54(3):937-945
  7. Spinks et al., Nature (1958). 181:1397
  8. Corne et al., Brit.J.Pharm. (1958). 13(5):501-520
  9. Spinks et al., Brit.J.Pharm. (1958). 13(4):501-520
 
Prices
Code
Quantity
US $
€uro
L9043
10 mg
60.20
43.00
50 mg
240.80
172.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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