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Home Page > Alphabetical Index > GLUTANED

GLUTANED Prod. No l9048 - CAS # 148822-97-3
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Product Name GLUTANED
(Syn.: Gl-Nd)
Product Code l9048
GLUTANED

Nd(C5O4NH8)3 .7H2O
Molecular Formula Nd(C5O4NH8)3 .7H2O
Description

an anticoagulant.

Complex of lanthanide element‚ Nd(C5O4NH8)3 .7H2O ‚ synthetic.
 
Biological Activity

The lanthanide element from Glutaned replaces calcium in its complex with prothrombine‚ thus preventing the formation of thrombine and interrupting the blood coagulation process.


On rabbits‚ i.v.‚ the blood anticoagulating action appears after 0‚5-1 hour. In vivo‚ the maximum effect occurs after 3 hours‚ the duration of action is 5 hours [1]. In vitro‚ the action of 0.02 - 0.5 % solutions appears after 30.00 ± 0.08 seconds. Standard: 20.00 ± 0.06 seconds.
 
Chemical and Physical Properties
 
CAS No. 148822-97-3 Molecular Weight 708 Da.
RTECS Physical Form pink powder.
Merck Index No (13th Ed.) Melting point ~ 200°C.
PubChem SID Solubility well in water and ethanol.
Purity min. 97%. (chemical elemental analysis‚ IR) Optical Activity L enantiomer.
Toxicity (LD50)
Chemical Names Neodymium tris-hydrogeneglutaminate.
Storage & Reconstitution Recommendations store in dry state or in saline‚ at room temperature. Solution for use: 2.5% - 5%. Dose for one experiment in vivo: 5 mg.
Safety Recommendations Low toxicity.
 
Bibliographic References
  1. Divald et al., "Coagulants and anticoagulants in medicinal chemistry", Burger Ed., 3rd ed., Part II, Wiley Int., N.Y., (1970). 1092-1122
  2. Vestn. Mosc. Univ. Ser 2, Chimia (1992) (Russian). 33(6):565-570
 
Prices
Code
Quantity
US $
€uro
L9048
20 mg
77.00
55.00
100 mg
308.00
220.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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