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Home Page > Alphabetical Index > DIPLACIN

DIPLACIN Prod. No L9055 - CAS # 863-83-2
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Product Name DIPLACIN
Product Code L9055
DIPLACIN

C26H42Cl2N2O6
Molecular Formula C26H42Cl2N2O6
Description

a nicotinic cholinoreceptor antagonist at the neuromuscular junction; curare-like ganglioblocker.

Bis-quaternary quinuclidine derivative‚ C26H42Cl2N2O6 ‚ synthetic.
 
Biological Activity

Curare-form competitive anti-depolarizing muscle relaxant. Used for muscle relaxation and controlled breathing under narcosis during surgical operations. Can be used for tracheal intubation.



Less potent than d-Tubocurarin. In humans i.v. 1.5-2 mg/kg causes muscle relaxation without breathing suppression; 4-5 mg/kg in 4-5 min complete myorelaxation and apnoe for 20-30 min.



Gradual decurarization: after restoration of spontaneous breathing abdominal and limbs muscles relaxation for some time. To prolong the action of Diplacine the repeated dose must be 1.5-2 times lower.



The effect is antagonized by Proserine.

No histamine liberation‚ no laringo- or bronchoconstriction. High doses may induce 15-20 mmHg blood pressure increase.


For comparative information see the attached table.
 
Chemical and Physical Properties
 
CAS No. 863-83-2 Molecular Weight 549.53 Da.
RTECS Physical Form colorless crystal powder.
Merck Index No (13th Ed.) Melting point 182-189 °C.
PubChem SID Solubility in water‚ ethanol.
Purity min. 98%.

TLC ['Silufol UV-254'‚ MeOH-NH3 (25%) (10:1) Rf <0.1‚ control by the absence of starting platinecin with Rf 0.2. Visualization with UV-light‚ followed with Dragendorff's reagent];
NMR (in D2O).		 Optical Activity
Toxicity (LD50) mice (i.v.): 5.3 mg/kg.
Chemical Names 4‚4'-[m-phenylene-bis-(oxyethylene)]bis-[hexahydro-1-hydroxy-7-(hydroxymethyl)-H-pyrrolizinium dichloride; 1‚1'-[b‚b '-(m-phenylenedioxy)diethylene]bis-[4-hydroxy-6-(hydroxymethyl)-1-azoniabicyclo[3.3.0]octane dichloride.
Storage & Reconstitution Recommendations stable in dry state up to 100 °C; solutions are stable for 1-2 days. Solution for use: 10-3 M (2 mg in 3.64 ml).
Safety Recommendations highly toxic! Do not swallow nor inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Sadritdinov F., Farm.Toksikol (1962) (Russian). (SAR for polymethylene bis-quinuclidiniums) 25(3):327-335
  2. Mashkovsky M.D. Lekarstvennye Sredstva (Drugs) -Moscow, Meditzina, (1984). 1:260
 
Prices
Code
Quantity
US $
€uro
L9055
1 x 2 mg
81.20
58.00
5 x 2 mg
324.80
232.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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