Weak AChR antagonist. Phenyl analog of ACECLIDINE. Hypotensive. Antiarrhythmic. Sedative (cortex and reticulum). Good penetration of biological membranes.

Quinuclidine derivative, C₁₄H₁₇NO₂.HCl, synthetic.

• Molecular Weight : 267.75 Da.
  
  
• Melting Point : 246-250 °C.
  
  
• Solubility in : water, ethanol.
  
  
• Purity min. : min. 98%. (TLC [MeOH-NH3 25% (10:1), Rf: 0.41, Sulifol]).
  
  
• Physical Form : colorless crystal powder.
  
  
• Chemical Name : DL-3-benzoyloxyquinuclidine hydrochloride.
  
  
• Biological Activity : No actual mechanism of biological action is known.
  
  weak antagonist of M and N cholinoreceptors. changes the electrical activity of the brain. weak spasmolytic. causes hypotension due to moderate ganglioblocking and adrenolytic activity. sedative; enhances narcotics, hypnotics, analgesics and local anesthetics action.
  good penetration of biological membrane.
  does not relax skeletal muscles.
  
  
• Toxicity (LD₅₀) : rats (orally): 250 mg/kg.
  
  
• Storage recommendations : Store at room temperature. Solution for use:dissolve in water: 10-3^M (2 mg in 7.46 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : Do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 16852-81-6 (base), 7348-26-7 (HCl).
  
  
• Bibliography :
  
  1. Mashkovsky et al., Prog. Drug. Res. (1969). 13:294-339
  2. Leniva et al., Kardiologiya (1973) (Russian). (4):142-143
  3. Mashkovsky et al., Farm. Toxicol. (1962) (Russian). 25(6):32-37
  4. Ziatzeva et al., Farm. Toxicol. (1970) (Russian). 33(3):305-309