a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempoxime. Antioxidant, radical scavenger.

Piperidine derivative, C₉H₁₈N₂O. HCl, synthetic.

• Molecular Weight : 206.71 Da.
  
  
• Melting Point : ~266 °C (decomp.).
  
  
• Solubility in : water, ethanol.
  
  
• Purity min. : min. 98%.
  TLC [Silufol UV-254, MeOH:NH3(25%) Rf = 0.69, development with Dragendorff¨ reagent]; NMR (D2O).
  
  
• Physical Form : colorless crystal powder.
  
  
• Chemical Name : 2,2,6,6-tetramethylpiperidone-4 oxime hydrochloride.
  
  
• Biological Activity : For comparative information see the attached 3 tables.
  
  Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.
  
  Good to moderate penetration of biological membranes.
  Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPOXIME can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPOXIME.
  
  Potential antimitotic (ask for the TEMPIDONE data).
  
  
• Toxicity (LD₅₀) : mice (orally): 200-230mg/kg
  
  
• Storage recommendations : store at room temperature. Solution for use: dissolve in water: 10-³M (2 mg in 9.66 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 63467-53-8
  
  
• Bibliography :
  
  1. Brehteric et al., Nature (1959). 184:1707-1709
  2. Lutz et al., J. Org. Chem. (1962) 27(5):1695-1703
  3. Akhmedkhodzhaeva Kh.S. et al. in Farmakol. alkaloidov ikh proizvod., 1972, Ed. Sultanov M.B., Fan, Tashkent, USSR. 156-162
  4. Vezen A.E. et al., Dokl. Akad. Nauk Tadzh.SS (1985). CA 104:122584. 28 (6): 350-351