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Home Page > Alphabetical Index > TEMPOXIME

TEMPOXIME Prod. No L9057 - CAS # 63467-53-8
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Product Name TEMPOXIME
(Syn.: TMP=NOH)
Product Code L9057
TEMPOXIME

C9H18N2O. HCl
Molecular Formula C9H18N2O. HCl
Description

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempoxime. Antioxidant‚ radical scavenger.

Piperidine derivative‚ C9H18N2O. HCl ‚ synthetic.
 
Biological Activity

For comparative information see the attached 3 tables.


Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.


Good to moderate penetration of biological membranes.

Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPOXIME can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPOXIME.


Potential antimitotic (ask for the TEMPIDONE data).
 
Chemical and Physical Properties
 
CAS No. 63467-53-8 Molecular Weight 206.71 Da.
RTECS Physical Form colorless crystal powder.
Merck Index No (13th Ed.) Melting point ~266 °C (decomp.).
PubChem SID Solubility water‚ ethanol.
Purity min. 98%.

TLC [Silufol UV-254‚ MeOH:NH3(25%) Rf = 0.69‚ development with Dragendorff¨ reagent]; NMR (D2O).		 Optical Activity
Toxicity (LD50) mice (orally): 200-230mg/kg
Chemical Names 2‚2‚6‚6-tetramethylpiperidone-4 oxime hydrochloride.
Storage & Reconstitution Recommendations store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 9.66 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations do not swallow or inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Brehteric et al., Nature (1959). 184:1707-1709
  2. Lutz et al., J. Org. Chem. (1962) 27(5):1695-1703
  3. Akhmedkhodzhaeva Kh.S. et al. in Farmakol. alkaloidov ikh proizvod., 1972, Ed. Sultanov M.B., Fan, Tashkent, USSR. 156-162
  4. Vezen A.E. et al., Dokl. Akad. Nauk Tadzh.SS (1985). CA 104:122584. 28 (6): 350-351
 
Prices
Code
Quantity
US $
€uro
L9057
1 x 2 mg
51.80
37.00
5 x 2 mg
207.20
148.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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