a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempidol. Antioxidant, radical scavenger.

Piperidine derivative, C9H19NO.HCl, synthetic.

• Molecular Weight : 193.71 Da.
  
  
• Melting Point : decomp. >315 °C.
  
  
• Solubility in : water, ethanol.
  
  
• Purity min. : min. 98%.
  TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.53, development with Dragendorff¨ reagent); NMR (D2O).
  
  
• Physical Form : colorless crystal powder.
  
  
• Chemical Name : 2,2,6,6-tetramethylpiperidinol-4 hydrochloride.
  
  
• Biological Activity : For comparative information see the attached 2 tables.
  
  Cell permeant central nicotinic cholinoreceptor blocker without action on skeleton muscle innervation.
  
  Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPIDOL can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPIDOL.
  
  Potential antimitotic (ask for the TEMPIDONE data).
  
  
• Storage recommendations : store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 10.31 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 24303-88-5 (base), 79316-86-2 (HCl).
  
  
• Bibliography :
  
  1. Brehteric et al., Nature (1959). 184:1707-1709