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Home Page > Alphabetical Index > TEMPIDOL

TEMPIDOL Prod. No L9058 - CAS # 79316-86-2
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Product Name TEMPIDOL
(Syn.: TMP-OH)
Product Code L9058
TEMPIDOL

C9H19NO.HCl
Molecular Formula C9H19NO.HCl
Description

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempidol. Antioxidant‚ radical scavenger.

Piperidine derivative‚ C9H19NO.HCl ‚ synthetic.
 
Biological Activity

For comparative information see the attached 2 tables.


Cell permeant central nicotinic cholinoreceptor blocker without action on skeleton muscle innervation.


Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPIDOL can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPIDOL.


Potential antimitotic (ask for the TEMPIDONE data).
 
Chemical and Physical Properties
 
CAS No. 79316-86-2 Molecular Weight 193.71 Da.
RTECS Physical Form colorless crystal powder.
Merck Index No (13th Ed.) Melting point decomp. >315 °C.
PubChem SID Solubility water‚ ethanol.
Purity min. 98%.

TLC (Silufol UV-254‚ MeOH:NH3(25%) Rf 0.53‚ development with Dragendorff¨ reagent); NMR (D2O).		 Optical Activity
Toxicity (LD50)
Chemical Names 2‚2‚6‚6-tetramethylpiperidinol-4 hydrochloride.
Storage & Reconstitution Recommendations store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 10.31 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations do not swallow or inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Brehteric et al., Nature (1959). 184:1707-1709
 
Prices
Code
Quantity
US $
€uro
L9058
1 x 2 mg
47.60
34.00
5 x 2 mg
190.40
136.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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