a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempidine and Temechine. Antioxidant, radical scavenger.

Piperidine derivative, C₉H₁₉N.HCl, synthetic.

• Molecular Weight : 177.71 Da.
  
  
• Melting Point : 299-301 °C.
  
  
• Solubility in : water, ethanol.
  
  
• Purity min. : min. 98%.
  TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.26, development with Dragendorff¨ reagent); NMR (D2O).
  
  
• Physical Form : colorless crystal powder.
  
  
• Chemical Name : 2,2,6,6-tetramethylpiperidine hydrochloride.
  
  
• Biological Activity : For comparative information see the attached 4 tables.
  Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation [1-5].
  
  Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPIDINE can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPIDINE.
  
  Potential antimitotic (ask for the TEMPIDONE data).
  
  
• Toxicity (LD₅₀) : mice (orally): 220 mg/kg [1].
  mice (i.v.): 32.5 mg/kg.
  mice (i.p.): 94mg/kg.
  
  
• Storage recommendations : store at room temperature. Solution for use: dissolve in water: 10-³M (2 mg in 11.24 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 768-66-1 (base), 935-22-8 (HCl).
  
  
• Bibliography :
  
  1. Brehteric et al., Nature (1959). 184:1707-1709
  2. Lee et al., Nature (1958). 181:1717
  3. Spinks et al., Nature (1959). 181:1397
  4. Tichonenko V.M., Farm.Toxikol. (1962). 25(6): 689-705
  5. Filipport E. et al., Arch. Int. Pharmacod. Ther. (1962). 135(3-4):273-280
  6. Hall H.K., Jr., JACS (1957). 79(20): 5444-5447