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Home Page > Alphabetical Index > TEMPIDINE (TMP)

TEMPIDINE (TMP) Prod. No L9059 - CAS # 768-66-1
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Product Name TEMPIDINE (TMP)
(Syn.: TMP)
Product Code L9059
TEMPIDINE (TMP)

C9H19N.HCl
Molecular Formula C9H19N.HCl
Description

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempidine and Temechine. Antioxidant‚ radical scavenger.

Piperidine derivative‚ C9H19N.HCl ‚ synthetic.
 
Biological Activity

For comparative information see the attached 4 tables.

Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation [1-5].


Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPIDINE can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPIDINE.


Potential antimitotic (ask for the TEMPIDONE data).
 
Chemical and Physical Properties
 
CAS No. 768-66-1 Molecular Weight 177.71 Da.
RTECS Physical Form colorless crystal powder.
Merck Index No (13th Ed.) Melting point 299-301 °C.
PubChem SID Solubility water‚ ethanol.
Purity min. 98%.

TLC (Silufol UV-254‚ MeOH:NH3(25%) Rf 0.26‚ development with Dragendorff¨ reagent); NMR (D2O).		 Optical Activity
Toxicity (LD50) mice (orally): 220 mg/kg [1].

mice (i.v.): 32.5 mg/kg.

mice (i.p.): 94mg/kg.
Chemical Names 2‚2‚6‚6-tetramethylpiperidine hydrochloride.
Storage & Reconstitution Recommendations store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 11.24 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations do not swallow or inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Brehteric et al., Nature (1959). 184:1707-1709
  2. Lee et al., Nature (1958). 181:1717
  3. Spinks et al., Nature (1959). 181:1397
  4. Tichonenko V.M., Farm.Toxikol. (1962). 25(6): 689-705
  5. Filipport E. et al., Arch. Int. Pharmacod. Ther. (1962). 135(3-4):273-280
  6. Hall H.K., Jr., JACS (1957). 79(20): 5444-5447
 
Prices
Code
Quantity
US $
€uro
L9059
1 x 5 mg
61.60
44.00
5 x 5 mg
246.40
176.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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