TEMPIDINE - LATOXAN Technical Data Sheet
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L9059 TEMPIDINE
( TMP )

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempidine and Temechine. Antioxidant, radical scavenger.

  1. see annexed table : Comparison of basicity and lipophilicity of 8 nico...
  2. see annexed table : Quinuclidine / Piperidine Nicotinic Blockers (Auto...

Piperidine derivative, C9H19N.HCl, synthetic.


PRICES
QuantityUS DollarsEURO
5 mg 61.60 44.00
25 mg 246.40 176.00


  • Molecular Weight : 177.71 Da.

  • Melting Point : 299-301 °C.

  • Solubility in : water, ethanol.

  • Purity min. : min. 98%.
    TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.26, development with Dragendorff¨ reagent); NMR (D2O).

  • Physical Form : colorless crystal powder.

  • Chemical Name : 2,2,6,6-tetramethylpiperidine hydrochloride.

  • Biological Activity : For comparative information see the attached 4 tables.
    Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation [1-5].

    Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPIDINE can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPIDINE.

    Potential antimitotic (ask for the TEMPIDONE data).

  • Toxicity (LD50) : mice (orally): 220 mg/kg [1].
    mice (i.v.): 32.5 mg/kg.
    mice (i.p.): 94mg/kg.

  • Storage recommendations : store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 11.24 ml), stable for 1-2 days at 20°C.

  • Safety recommendations : do not swallow or inhale; avoid eye and skin contact.

  • CAS Reg. No. : 768-66-1 (base), 935-22-8 (HCl).

  • Bibliography :
    1. Brehteric et al., Nature (1959). 184:1707-1709
    2. Lee et al., Nature (1958). 181:1717
    3. Spinks et al., Nature (1959). 181:1397
    4. Tichonenko V.M., Farm.Toxikol. (1962). 25(6): 689-705
    5. Filipport E. et al., Arch. Int. Pharmacod. Ther. (1962). 135(3-4):273-280
    6. Hall H.K., Jr., JACS (1957). 79(20): 5444-5447



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    Revised : 26/04/2007 10:28 - Copyright © Latoxan