AChR agonist. Rigid bicyclic analog of ACh and ARECOLINE. Good penetration of biological membranes.

Quinuclidine derivative, C₁₀H₁₇NO₂.HCl, synthetic.

• Molecular Weight : 219.71 Da.
  
  
• Melting Point : 162-163 °C.
  
  
• Solubility in : water, ethanol.
  
  
• Purity min. : min. 99.5%.
  TLC [CHCl3-MeOH-NH3 25% (10:10:1), Rf=0.90, Sulifol]; 13C NMR (D2O)
  
  
• Chemical Name : 3-ethoxycarbonylquinuclidine hydrochloride.
  
  
• Biological Activity : Weak muscarinic agonist. Weak nicotinic antagonist.
  
  
• Toxicity (LD₅₀) : mice (orally): ~1 358 mg/kg.
  
  
• Storage recommendations : store at room temperature. Solution for use: dissolve in water: 10-³M (2 mg in 9.13 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : do not swallow; avoid extra-large quantity inhalation.
  
  
• CAS Reg. No. : 112300-33-1
  
  
• Bibliography :
  
  1. Burkin et al., Khim. Farm. Zh. (1992). (5):12-13
  2. Ziatzeva, Farm. Toxikol (1972) (Russian). 35(6):153-155
  3. Sharapov I.V., Farm, Toksikol. (1972). (Russian). 25(6):695-698