Latoxan

Print this Print this page

LATOXAN
20 Rue Léon Blum
26000 Valence - France

Venoms - Toxins - Alkaloids - Plant Compounds - Ion Channel & Receptor Ligands

Google Custom Search
 Phone : (+33) 47 541 9191
Fax : (+33) 47 541 9199
Email : contact@latoxan.com
Contact Us

Home Page > Alphabetical Index > ACECLIDINE

ACECLIDINE Prod. No L9065 - CAS # 827-61-2
< First < Previous - Next > Last >

Product Name ACECLIDINE
(Syn.: Glaucostat‚ Glaudin‚ Glaunorm‚ Q-OAc)
Product Code L9065
ACECLIDINE

C9H15NO2 .C7H6O3
Molecular Formula C9H15NO2 .C7H6O3
Description

a selective M-AChR agonist. Rigid bicyclic analog of ACh. Good penetration of biological membranes.

Quinuclidine derivative‚ C9H15NO2 .C7H6O3 ‚ synthetic.
 
Biological Activity

5-10 µg/kg i.v. in cats cause hypotension. 1.5x10-6 M in cats cause myosis. 3x10-8 M in isolated rabbit intestine cause contractions.


good penetration of biological membrane.


more potent than NMQ-OAc [1-4].
 
Chemical and Physical Properties
 
CAS No. 827-61-2 Molecular Weight 307.34 Da.
RTECS Physical Form colorless crystal powder.
Merck Index No (13th Ed.) Melting point 137-141 °C.
PubChem SID 17396908 Solubility water‚ ethanol.
Purity min. 98%. (TLC (MeOH-NH3 25% [10:1]‚ Rf=0.40‚ Sulifol); NMR (D2O)) Optical Activity
Toxicity (LD50) mice (orally) >650mg/kg
Chemical Names DL-3-acetoxyquinuclidine salicylate.
Storage & Reconstitution Recommendations Store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 6.51 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations
 
Bibliographic References
  1. Mashkovsky et al., Prog. Drug. Res. (1969). 13:294-339
  2. Wienstein et al., Molec. Pharmacol. (1975). 11(5):671-689
  3. Mashkovsky et al., Khim. Pharm. Zh. (1967) (Russian). (3):3
  4. Barlow et al., Molec. Pharmacol. (1975). 11(5):690-693
 
Prices
Code
Quantity
US $
€uro
L9065
2 mg
74.20
53.00
10 mg
296.80
212.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

[ Ordering Information ] - [ Privacy Statement ] - [ Infos Légales ] - [ Contact Us ]

© Copyright of Latoxan SAS 2008 - France.
For Research Pharmaceutical and Medical Purposes Only.
DOCUMENT URL : http://www.latoxan.com/PHP/00000275.php
ModelBtx.html - Last Update 02/09/2010 15:10:37