a weak muscarinic AChR agonist. Bicyclic analog of ACh. Poor penetration of biological membranes.

Quaternary quinuclidine derivative, C₁₀H₁₈INO₂, synthetic.

• Molecular Weight : 311.16 Da.
  
  
• Melting Point : 163-165 °C.
  
  
• Solubility in : very soluble in water, ethanol.
  
  
• Purity min. : min. 98%.
  TLC ['Silufol UV-254', MeOH-NH3 (25%) 10:1 , Rf < 0.1; Rf of starting Q-Bn = 0.18. Visualization with Dragendorff's reagent]; NMR (in D2O).
  
  
• Chemical Name : N-methyl- DL-3-acetoxyquinuclidinium iodide, 1-methyl- DL-3-acetoxyquinuclidinium iodide.
  
  
• Biological Activity : 100-500 µg/kg i.v. in cats cause hypotension; in isolated rabbit intestine 6.4x10-⁴ M cause contractions; in frog isolated rectus abdominus ranges from 3.2x10-⁴ to 1.6x10-⁴ M cause slight contractions.
  less potent than ACECLIDINE.
  low penetration of biological membrane.
  
  
• Toxicity (LD₅₀) : mice (orally) 650mg/kg
  
  
• Storage recommendations : store at room temperature in a dark place. Solution for use: dissolve in water: 10-³M (2 mg in 6.43 ml), stable for 1-2 days at 20°C.
  
  
• Safety recommendations : Do not swallow or inhale; avoid eye and skin contact.
  
  
• CAS Reg. No. : 57345-44-5
  
  
• Bibliography :
  
  1. Mashkovsky et al., Prog. Drug. Res. (1969). 13:294-339
  2. Wienstein et al., Molec. Pharmacol. (1975). 11(5):671-689
  3. Mashkovsky et al., Khim. Pharm. Zh. (1967) (Russian). (3):3
  4. Barlow et al., Molec. Pharmacol. (1975). 11(5):690-693