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Home Page > Alphabetical Index > NMQ-OAc

NMQ-OAc Prod. No L9066 - CAS # 57345-44-5
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Product Name NMQ-OAc
Product Code L9066
NMQ-OAc

C10H18INO2
Molecular Formula C10H18INO2
Description

a weak muscarinic AChR agonist. Bicyclic analog of ACh. Poor penetration of biological membranes.

Quaternary quinuclidine derivative‚ C10H18INO2 ‚ synthetic.
 
Biological Activity

100-500 µg/kg i.v. in cats cause hypotension; in isolated rabbit intestine 6.4x10-4 M cause contractions; in frog isolated rectus abdominus ranges from 3.2x10-4 to 1.6x10-4 M cause slight contractions.

less potent than ACECLIDINE.

low penetration of biological membrane.
 
Chemical and Physical Properties
 
CAS No. 57345-44-5 Molecular Weight 311.16 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 163-165 °C.
PubChem SID Solubility very soluble in water‚ ethanol.
Purity min. 98%.

TLC ['Silufol UV-254'‚ MeOH-NH3 (25%) 10:1 ‚ Rf < 0.1; Rf of starting Q-Bn = 0.18. Visualization with Dragendorff's reagent]; NMR (in D2O).		 Optical Activity
Toxicity (LD50) mice (orally) 650mg/kg
Chemical Names N-methyl- DL-3-acetoxyquinuclidinium iodide‚ 1-methyl- DL-3-acetoxyquinuclidinium iodide.
Storage & Reconstitution Recommendations store at room temperature in a dark place. Solution for use: dissolve in water: 10-3M (2 mg in 6.43 ml)‚ stable for 1-2 days at 20°C.
Safety Recommendations Do not swallow or inhale; avoid eye and skin contact.
 
Bibliographic References
  1. Mashkovsky et al., Prog. Drug. Res. (1969). 13:294-339
  2. Wienstein et al., Molec. Pharmacol. (1975). 11(5):671-689
  3. Mashkovsky et al., Khim. Pharm. Zh. (1967) (Russian). (3):3
  4. Barlow et al., Molec. Pharmacol. (1975). 11(5):690-693
 
Prices
Code
Quantity
US $
€uro
L9066
1 x 2 mg
96.60
69.00
5 x 2 mg
386.40
276.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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