Nicotinic receptor antagonist; ganglioblocker; good penetration of biological membranes.

Piperidine derivative, C10H19NO .HI, synthetic.

• Molecular Weight : 297.17 Da.
  
  
• Melting Point : 195-197 °C.
  
  
• Solubility in : well in water and ethanol.
  
  
• Purity min. : min. 98%.
  
  
• Physical Form : colorless crystals.
  
  
• Chemical Name : 1,2,2,6,6-pentamethylpiperidone hydroiodide.
  
  
• Biological Activity : Non-quaternary ganglioblocker, less potent than Pempidine and Tempidine [1-3]. Good penetration of biological membranes.
  For detailed information see the 3 attached tables.
  
  
• Toxicity (LD₅₀) : mice (orally): 200-230 mg/kg.
  
  
• Storage recommendations : Stable when kept dry, store in a dark place, at room temperature. Solution for use: 10-³ M
  
  
• Safety recommendations : Do not swallow nor inhale; avoid eyes and skin contact.
  
  
• CAS Reg. No. : 5554-54-1 (base)
  
  
• Bibliography :
  
  1. Brehteric et al., Nature (1959). 184:1707-1709
  2. Lutz et al., J. Org. Chem. (1962) 27(5):1695-1703
  3. Philippot E. et al., Arch. Int. Pharmacodyn. Ther. (1962). 135(3-4):273-280