a blocker of Ca2+ release from sarcoplasmic reticulum; skeletal muscle relaxant.

Hydantoin derivative, C₁₄H₉N₄NaO₅, synthetic.

• Molecular Weight : 336.23 Da.
  
  
• Melting Point : 265 °C (decomp.).
  
  
• Solubility in : moderately in methanol or dilute alkaline solution, slightly in water.
  
  
• Purity min. : min. 99%. (HPLC)
  
  
• Physical Form : orange solid.
  
  
• Chemical Name : 1-[[[5-(4-Nitrophenyl)-2-furanyl]-methylene]imino]-2,4-imidazolidinedione sodium salt.
  
  
• Biological Activity : selectively inhibits the Ca-induced Ca²⁺ release mechanism from sarcoplasmic reticulum in guinea pig skeletal muscle, only at physiological temperature (38°C), under various conditions. (50 µM at low temperature (20 °C) does not inhibit this mechanism) [1].
  
  
• Toxicity (LD₅₀) : mice (i.v.): > 7 g/kg
  
  
• Storage recommendations : store at room temperature.
  
  
• CAS Reg. No. : 7261-97-4
  
  
• Merck Index 11th Ed. : 2814
  
  
• Bibliography :
  
  1. Ohta et al., Eur. J. Pharmacol. (1990). 178:11
  2. Amelink et al., Eur. J. Pharmacol. (1990). 179(1-2):187
  3. Frandsen et al., Proc. Natl. Acad. Sci. USA (1992). 89:2590