NICARDIPINE HYDROCHLORIDE - LATOXAN Technical Data Sheet
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L9069 NICARDIPINE HYDROCHLORIDE
( YC-93 HCl, Nicodel, Perdipine )

a L-type Ca2+ channels blocker; antihypertensive.

Dihydropyridine derivative, C26H29N3O6.HCl, synthetic.


PRICES
QuantityUS DollarsEURO
200 mg 32.20 23.00
1 g 128.80 92.00


  • Molecular Weight : 516 Da.

  • Melting Point : 168-170 °C.

  • Solubility in : in dilute aqueous alkaline solution and chloroform-methanol (1:1); not in water.

  • Purity min. : min. 99%. (TLC)

  • Physical Form : light yellow solid.

  • Chemical Name : 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2- [methyl-(phenylmethyl)amino]ethyl ester hydrochloride.

  • Biological Activity : Inhibits L-type Ca2+ channels in chick sensory neurons [4].
    Antianginal; antihypertensive.

  • Toxicity (LD50) : rat (orally): 187 mg/kg; rat (i.v.): 15.5 mg/kg;
    mice (orally): 322 mg/kg; mice (i.v.): 19.9 mg/kg.
    rat (i.p.): 155 mg/kg; rat (s.c.): 683 mg/kg;
    mice (i.p.): 123 mg/kg; mice (s.c.): 540 mg/kg.

  • Storage recommendations : stable when kept dry; store at room temperature in a dark place.

  • Safety recommendations : do not inhale nor swallow, prevent contact with skin.

  • CAS Reg. No. : 54527-84-3.

  • Merck Index 11th Ed. : 6403

  • Bibliography :
    1. Triggle et al., TiPS (1989). 10:507-511
    2. Sato et al., "Mechanism of Mesaconitine-induced contractile response in guinea-pig ileum." J. Pharm. Pharmacol. (1980). 7:249
    3. Chang et al., Can. J. Physiol. Pharmacol. (1989). 67:1493
    4. Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflügers Arch. (1989). 414:150-156



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan