a L-type Ca²⁺ channels blocker; antihypertensive.

Dihydropyridine derivative, C₂₆H₂₉N₃O₆.HCl, synthetic.

• Molecular Weight : 516 Da.
  
  
• Melting Point : 168-170 °C.
  
  
• Solubility in : in dilute aqueous alkaline solution and chloroform-methanol (1:1); not in water.
  
  
• Purity min. : min. 99%. (TLC)
  
  
• Physical Form : light yellow solid.
  
  
• Chemical Name : 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2- [methyl-(phenylmethyl)amino]ethyl ester hydrochloride.
  
  
• Biological Activity : Inhibits L-type Ca²⁺ channels in chick sensory neurons [4].
  Antianginal; antihypertensive.
  
  
• Toxicity (LD₅₀) : rat (orally): 187 mg/kg; rat (i.v.): 15.5 mg/kg;
  mice (orally): 322 mg/kg; mice (i.v.): 19.9 mg/kg.
  rat (i.p.): 155 mg/kg; rat (s.c.): 683 mg/kg;
  mice (i.p.): 123 mg/kg; mice (s.c.): 540 mg/kg.
  
  
• Storage recommendations : stable when kept dry; store at room temperature in a dark place.
  
  
• Safety recommendations : do not inhale nor swallow, prevent contact with skin.
  
  
• CAS Reg. No. : 54527-84-3.
  
  
• Merck Index 11th Ed. : 6403
  
  
• Bibliography :
  
  1. Triggle et al., TiPS (1989). 10:507-511
  2. Sato et al., "Mechanism of Mesaconitine-induced contractile response in guinea-pig ileum." J. Pharm. Pharmacol. (1980). 7:249
  3. Chang et al., Can. J. Physiol. Pharmacol. (1989). 67:1493
  4. Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflügers Arch. (1989). 414:150-156