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Home Page > Alphabetical Index > NICARDIPINE HCl

NICARDIPINE HCl Prod. No L9069 - CAS # 54527-84-3
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Product Name NICARDIPINE HCl
(Syn.: YC-93 HCl‚ Nicodel‚ Perdipine)
Product Code L9069
NICARDIPINE HCl

C26H29N3O6.HCl
Molecular Formula C26H29N3O6.HCl
Description

a L-type Ca2+ channels blocker; antihypertensive.

Dihydropyridine derivative‚ C26H29N3O6.HCl ‚ synthetic.
 
Biological Activity

Inhibits L-type Ca2+ channels in chick sensory neurons [4].

Antianginal; antihypertensive.
 
Chemical and Physical Properties
 
CAS No. 54527-84-3 Molecular Weight 516 Da.
RTECS Physical Form light yellow solid.
Merck Index No (13th Ed.) 6403 Melting point 168-170 °C.
PubChem SID Solubility in dilute aqueous alkaline solution and chloroform-methanol (1:1); not in water.
Purity min. 99%. (TLC) Optical Activity
Toxicity (LD50) rat (orally): 187 mg/kg; rat (i.v.): 15.5 mg/kg;

mice (orally): 322 mg/kg; mice (i.v.): 19.9 mg/kg.

rat (i.p.): 155 mg/kg; rat (s.c.): 683 mg/kg;

mice (i.p.): 123 mg/kg; mice (s.c.): 540 mg/kg.
Chemical Names 1‚4-Dihydro-2‚6-dimethyl-4-(3-nitrophenyl)-3‚5-pyridinedicarboxylic acid methyl 2- [methyl-(phenylmethyl)amino]ethyl ester hydrochloride.
Storage & Reconstitution Recommendations stable when kept dry; store at room temperature in a dark place.
Safety Recommendations do not inhale nor swallow‚ prevent contact with skin.
 
Bibliographic References
  1. Triggle et al., TiPS (1989). 10:507-511
  2. Sato et al., "Mechanism of Mesaconitine-induced contractile response in guinea-pig ileum." J. Pharm. Pharmacol. (1980). 7:249
  3. Chang et al., Can. J. Physiol. Pharmacol. (1989). 67:1493
  4. Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflügers Arch. (1989). 414:150-156
 
Prices
Code
Quantity
US $
Euro (¤)
L9069
200 mg
32,20
23,00
1000 mg
128,80
92,00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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