a L-type Ca²⁺ channels blocker; antihypertensive.

Dihydropyridine derivative, C₁₇H₁₈N₂O₆, synthetic.

• Molecular Weight : 346.34 Da.
  
  
• Melting Point : 172-174 °C.
  
  
• Solubility in : freely in acetone, chloroform, DMSO; less in ethanol; not in water.
  
  
• Purity min. : min. 98%. (TLC)
  
  
• Physical Form : yellow crystals.
  
  
• Chemical Name : 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester.
  
  
• Biological Activity : Inhibits L-type Ca²⁺ channels in chick sensory neurons [4].
  Antihypertensive; vasodilator; antianginal.
  Has teratogenic effect on some animal species
  
  
• Toxicity (LD₅₀) : orally: rat: 1 022 mg/kg; mice: 310 mg/kg; cat: 100 mg/kg; rabbit: 504 mg/kg
  i.v.: rat: 6 mg/kg; mice: 4.20 mg/kg; rabbit: 2 mg/kg
  i.p.: rat: 230 mg/kg; mice: 185 mg/kg; cat: 190 mg/kg
  s.c.: rat: > 10 mg/kg; mice: > 10 mg/kg
  
  
• Storage recommendations : Stable when kept dry; store at +4°C, in dark place. Caution: the solution is very light-sensitive.
  
  
• Safety recommendations : Do not inhale nor swallow; prevent contact from skin.
  
  
• CAS Reg. No. : 21829-25-4.
  
  
• RTECS No. : US7975000
  
  
• Merck Index 11th Ed. : 6441
  
  
• Bibliography :
  
  1. Triggle et al., TiPS (1989). 10:507-511
  2. Weiss et al., "The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity." Science (1990). 247:1474-1477
  3. Trabrizchi et al., "Benextramine and nifedipine distinguish between sub-classes of a1-adrenoreceptors." Life Sciences (1989). 45:2577
  4. Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflügers Arch. (1989). 414:150-156