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Home Page > Alphabetical Index > NIFEDIPINE

NIFEDIPINE Prod. No L9070 - CAS # 21829-25-4
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Product Name NIFEDIPINE
(Syn.: Adalat‚ BAY a 1040‚ Citilat‚ Nifelat)
Product Code L9070
NIFEDIPINE

C17H18N2O6
Molecular Formula C17H18N2O6
Description

a L-type Ca2+ channels blocker; antihypertensive.

Dihydropyridine derivative‚ C17H18N2O6 ‚ synthetic.
 
Biological Activity

Inhibits L-type Ca2+ channels in chick sensory neurons [4].

Antihypertensive; vasodilator; antianginal.

Has teratogenic effect on some animal species
 
Chemical and Physical Properties
 
CAS No. 21829-25-4 Molecular Weight 346.34 Da.
RTECS US7975000 Physical Form yellow crystals.
Merck Index No (13th Ed.) 6441 Melting point 172-174 °C.
PubChem SID Solubility freely in acetone‚ chloroform‚ DMSO; less in ethanol; not in water.
Purity min. 98%. (TLC) Optical Activity
Toxicity (LD50) orally: rat: 1 022 mg/kg; mice: 310 mg/kg; cat: 100 mg/kg; rabbit: 504 mg/kg

i.v.: rat: 6 mg/kg; mice: 4.20 mg/kg; rabbit: 2 mg/kg

i.p.: rat: 230 mg/kg; mice: 185 mg/kg; cat: 190 mg/kg

s.c.: rat: > 10 mg/kg; mice: > 10 mg/kg
Chemical Names 1‚4-Dihydro-2‚6-dimethyl-4-(2-nitrophenyl)-3‚5-pyridinedicarboxylic acid dimethyl ester.
Storage & Reconstitution Recommendations Stable when kept dry; store at +4°C‚ in dark place. Caution: the solution is very light-sensitive.
Safety Recommendations Do not inhale nor swallow; prevent contact from skin.
 
Bibliographic References
  1. Triggle et al., TiPS (1989). 10:507-511
  2. Weiss et al., "The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity." Science (1990). 247:1474-1477
  3. Trabrizchi et al., "Benextramine and nifedipine distinguish between sub-classes of a1-adrenoreceptors." Life Sciences (1989). 45:2577
  4. Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflügers Arch. (1989). 414:150-156
 
Prices
Code
Quantity
US $
€uro
L9070
1 g
53.20
38.00
5 g
212.80
152.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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