a weak non selective K⁺ channels blocker; convulsant; induces acetylcholine release; induces GABA neurons depolarization.

Pyridine derivative, C₅H₆N₂, synthetic.

• Molecular Weight : 94.11 Da.
  
  
• Melting Point : 155-158 °C.
  
  
• Solubility in : soluble in water.
  
  
• Purity min. : min. 97%.
  
  
• Physical Form : white to tan solid.
  
  
• Biological Activity : 10-⁴ - 10-⁵ M increases severalfold the release of acetylcholine from rat striatal slices superfused with an eserine-containing, choline-free medium, and causes stoichiometric decreases in the release of choline [3].
  
  
• Toxicity (LD₅₀) : rat (orally): 21 mg/kg; mice (orally): 19 mg/kg
  mice (i.v.): 7 mg/kg; rabbit (i.v.): 5.5 mg/kg
  rat (i.p.): 6.5 mg/kg; mice (i.p.): 10 mg/kg
  rat (s.c.): 19 mg/kg
  
  
• Storage recommendations : store at room temperature.
  
  
• Safety recommendations : very toxic.
  
  
• CAS Reg. No. : 504-24-5
  
  
• RTECS No. : US1750000
  
  
• Bibliography :
  
  1. Rutecki P.A. et al., "4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition." J. Neurophysiol. (1987). 57(6):1911-1924
  2. Ogata N. et al., "Differential inhibition of a transient K+ current by chlorpromazine and 4-aminopyridine in neurones of the rat dorsal root ganglia." Br. J. of Pharmacol. (1993). 109(4):1239-1246
  3. Buyukuysal R.L. et al., "4-Aminopyridine Increases Acetylcholine Release Without Diminishing Membrane Phosphatidylcholine." J. of Neurochem. (1990). 54(4):1302-1309
  4. Avoli M. et al., "4-Aminopyridine induces a long-lasting depolarizing GABA-ergic potential in human neocortical and hippocampal neurons maintained in vitro." Neurosci. Lett. (1988). 94(3):327-332
  5. Heemskerk F.M.J. et al., "4-Aminopyridine stimulates B-50 (GAP43) phosphorilation and [3H]Noradrenaline release in rat hippocampal slices." J. Neurochem. (1990). 54:863
  6. Robertson D.W. et al., "Potassium channel modulators: scientific applications and therapeutic promise." J. Med. Chem. (1990). 33(6):1529