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Home Page > Alphabetical Index > AMINOPYRIDINE (4-)

AMINOPYRIDINE (4-) Prod. No L9071 - CAS # 504-24-5
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Product Name AMINOPYRIDINE (4-)
(Syn.: 4-AP)
Product Code L9071
AMINOPYRIDINE (4-)

C5H6N2
Molecular Formula C5H6N2
Description

a weak non selective K+ channels blocker; convulsant; induces acetylcholine release; induces GABA neurons depolarization.

Pyridine derivative‚ C5H6N2 ‚ synthetic.
 
Biological Activity

10-4 - 10-5 M increases severalfold the release of acetylcholine from rat striatal slices superfused with an eserine-containing‚ choline-free medium‚ and causes stoichiometric decreases in the release of choline [3].
 
Chemical and Physical Properties
 
CAS No. 504-24-5 Molecular Weight 94.11 Da.
RTECS US1750000 Physical Form white to tan solid.
Merck Index No (13th Ed.) Melting point 155-158 °C.
PubChem SID Solubility soluble in water.
Purity min. 97%. Optical Activity
Toxicity (LD50) rat (orally): 21 mg/kg; mice (orally): 19 mg/kg

mice (i.v.): 7 mg/kg; rabbit (i.v.): 5.5 mg/kg

rat (i.p.): 6.5 mg/kg; mice (i.p.): 10 mg/kg

rat (s.c.): 19 mg/kg
Chemical Names
Storage & Reconstitution Recommendations store at room temperature.
Safety Recommendations very toxic.
 
Bibliographic References
  1. Rutecki P.A. et al., "4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition." J. Neurophysiol. (1987). 57(6):1911-1924
  2. Ogata N. et al., "Differential inhibition of a transient K+ current by chlorpromazine and 4-aminopyridine in neurones of the rat dorsal root ganglia." Br. J. of Pharmacol. (1993). 109(4):1239-1246
  3. Buyukuysal R.L. et al., "4-Aminopyridine Increases Acetylcholine Release Without Diminishing Membrane Phosphatidylcholine." J. of Neurochem. (1990). 54(4):1302-1309
  4. Avoli M. et al., "4-Aminopyridine induces a long-lasting depolarizing GABA-ergic potential in human neocortical and hippocampal neurons maintained in vitro." Neurosci. Lett. (1988). 94(3):327-332
  5. Heemskerk F.M.J. et al., "4-Aminopyridine stimulates B-50 (GAP43) phosphorilation and [3H]Noradrenaline release in rat hippocampal slices." J. Neurochem. (1990). 54:863
  6. Robertson D.W. et al., "Potassium channel modulators: scientific applications and therapeutic promise." J. Med. Chem. (1990). 33(6):1529
 
Prices
Code
Quantity
US $
€uro
L9071
5 g
37.80
27.00
25 g
151.20
108.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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