K⁺ channels blocker; cholinoreceptors antagonist; ganglioblocker.

C₈H₂₀ClN ‚ synthetic.

The exposure of rat tracheal segments to threshold/subthreshold concentrations of TEA produces remarkable Airway Hyperresponsiveness (AH) to cooling provocation [Chand N.].


K⁺ channel blockade is involved in the induction of non specific AH in this model [4]. At the concentration of 10 mM: EC₅₀ = 3.4 µM (1.8 - 6.4).


1 mM blocks InsP3-induced Ca²⁺ release in microsomal fractions isolated from rat brain incubated in media containing 100 mM KCl. Decreases the InsP₃-induced Ca²⁺ release by 80 ± 5% [5].

1. Barlow, Molec. Pharm. (1971). 7:357-366
2. Kellet Jr., J. Pharm. Sci. (1965). 54(3):883-887
3. Eldefrawi M.E. et al., "Permeability of the abdominal nerve cord of the american cockroach, Periplaneta americana L. to quaternary ammonium salts." J. Exp. Biol. (1967). 46:1-12
4. Chand N. et al., "Potassium channel blockade induces nonspecific airway hyperractivity in rat isolated trachea: pharmacologic modulation." Pharm. Comm. (1994). 4(3):173-179
5. Shah J. et al., "Potassium-channel blockers inhibit inositol triphosphate-induced calcium release in the microsomal fractions isolated from the rat brain." Biochem. J. (1988). 250:617-620