Calcium antagonist; inhibitor of Ca²⁺/Mg²⁺ ATPase.

Complex of Ruthenium elements, Cl₆H₄₂N₁₄O₂Ru₃, synthetic.

• Molecular Weight : 786.35 Da.
  
  
• Solubility in : well in water and ammonia.
  
  
• Purity min. : min. 98%
  
  
• Physical Form : red-brown powder.
  
  
• Chemical Name : trans-Tetradecaaminedi-µ-oxotriruthenium6+ hexachloride.
  
  
• Biological Activity : As a calcium antagonist, its inhibitory mechanism differs from that of other antagonists [1]. Its selective interaction with Calmodulin may explain some of the following pharmacological actions:
  
  - inhibits Ca²⁺ uptake in mitochondria and Ca²⁺ release from sarcoplasmic reticulum in skeletal and cardiac muscles.
  - inhibits Ca²⁺-ATPase and ATP independent Ca²⁺ binding with rat heart sarcolemma.
  - prevents Capsaicin-induced transmitter release from primary afferent nerve terminals.
  
  
• Storage recommendations : store at room temperature.
  
  
• Safety recommendations : do not ingest nor inhale; avoid skin contact.
  
  
• CAS Reg. No. : 11103-72-3
  
  
• Merck Index 11th Ed. : 8273
  
  
• Bibliography :
  
  1. Masuoka et al., "Effects of Ruthenium Red on Activation of Ca²⁺-dependent cyclic nucleotide phosphodiesterase." Biochem. Biophys. Res. Comm. (1990). 169(1):315-322
  2. Amman et al., "Capsaicin desensitization in vivo is inhibited by Ruthenium Red." Eur. J. Pharmacol. (1990). 186(2-3):169
  3. Amman et al., "Capsaicin-induced stimulation of polymodal nociceptors is antagonised by Ruthenium Red independently of extracellular calcium." Neuroscience (1989). 32(1):255
  4. Luthra et al., "The inhibition of calcium uptake and release by rat liver mitochondria by Ruthenium Red." FEBS Letters (1977). 81(1):142