an intracellular calcium antagonist; protein kinase C inhibitor.

C₂₂H₃₇NO₅ .HCl, synthetic.

• Molecular Weight : 432 Da.
  
  
• Melting Point : 94-97 °C.
  
  
• Solubility in : soluble in water.
  
  
• Purity min. : min. 97%.
  
  
• Physical Form : white powder.
  
  
• Chemical Name : 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride.
  
  
• Biological Activity : reduces Ca²⁺ influx and efflux in guinea pig ileum, and caffeine-induced release of Ca2+ from sarcoplasmic reticulum vesicles [2].
  
  In quin2-loaded human platelets, has a weak inhibitory effect on Ca²⁺ movements but a more effective inhibition of secretion, including that evoked by TPA, a direct activator of protein kinase C [2].
  
  
• Storage recommendations : store at room temperature.
  
  
• CAS Reg. No. : 53464-72-5
  
  
• Bibliography :
  
  1. Scharff et al., "Effect of trifluoperazine, compound 48/80, TMB-8 and verapamil on the rate of calmodulin binding to erythrocyte Ca⁺⁺ - ATPase." Biochem. Biophys. Acta (1984). 772:29-36
  2. Simpson et al., "TMB-8 inhibits secretion evoked by phorbol ester at basal cytoplasmic free calcium in quin2-loaded platelets much more effectively than it inhibits thrombin-induced calcium mobilisation." FEBS Letters (1984). 176(1):139-143
  3. Chiou et al., "Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition." Biochemistry 1993 53:279-285
  4. Yamada et al., "Intracellular Ca²⁺ antagonist TMB-8 blocks catecholamine secretion evoked by caffeine and acetylcholine from perfused cat adrenal glands in the absence of extracellular Ca²⁺." Neurosc. Lett. (1988). 90:338-342