TMB-8 HCl - LATOXAN Technical Data Sheet
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L9076 TMB-8 HCl

an intracellular calcium antagonist; protein kinase C inhibitor.

C22H37NO5 .HCl, synthetic.


PRICES
QuantityUS DollarsEURO
30 mg 60.20 43.00
150 mg 240.80 172.00


  • Molecular Weight : 432 Da.

  • Melting Point : 94-97 °C.

  • Solubility in : soluble in water.

  • Purity min. : min. 97%.

  • Physical Form : white powder.

  • Chemical Name : 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride.

  • Biological Activity : reduces Ca2+ influx and efflux in guinea pig ileum, and caffeine-induced release of Ca2+ from sarcoplasmic reticulum vesicles [2].

    In quin2-loaded human platelets, has a weak inhibitory effect on Ca2+ movements but a more effective inhibition of secretion, including that evoked by TPA, a direct activator of protein kinase C [2].

  • Storage recommendations : store at room temperature.

  • CAS Reg. No. : 53464-72-5

  • Bibliography :
    1. Scharff et al., "Effect of trifluoperazine, compound 48/80, TMB-8 and verapamil on the rate of calmodulin binding to erythrocyte Ca++ - ATPase." Biochem. Biophys. Acta (1984). 772:29-36
    2. Simpson et al., "TMB-8 inhibits secretion evoked by phorbol ester at basal cytoplasmic free calcium in quin2-loaded platelets much more effectively than it inhibits thrombin-induced calcium mobilisation." FEBS Letters (1984). 176(1):139-143
    3. Chiou et al., "Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition." Biochemistry 1993 53:279-285
    4. Yamada et al., "Intracellular Ca2+ antagonist TMB-8 blocks catecholamine secretion evoked by caffeine and acetylcholine from perfused cat adrenal glands in the absence of extracellular Ca2+." Neurosc. Lett. (1988). 90:338-342



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    Revised : 26/04/2007 10:28 - Copyright © Latoxan