Potent inhibitor of Ca²⁺/Mg²⁺ - ATPase.

Benzohydroquinone, C₁₄H₂₂O₂, synthetic.

• Molecular Weight : 222.3 Da.
  
  
• Solubility in : soluble in methanol and organic solvents
  
  
• Purity min. : min 98%. (HPLC)
  
  
• Physical Form : off-white solid.
  
  
• Chemical Name : 2,5-Di-(t-butyl)-1,4-hydroquinone; 2,5-di-(t-butyl)-1,4-benzohydroquinone.
  
  
• Biological Activity : Ca²⁺ mobilizer; the effect of BHQ is to inhibit Ca²⁺ sequestration by the stores and not to stimulate aCa²⁺ efflux pathway, suggesting that its inhibitory effects on microsomal Ca²⁺-ATPase probably underlie its effects on intracellular Ca²⁺ stores.[1] In permeabilized rat hepatocytes, a maximal concentration (25 µM) mobilized 70 % of sequestered Ca²⁺ and a half-maximal effect was produced by 1.7 µM.
  
  Although BHQ has some selectivity for the Ca²⁺ transport system of Inositol 1,4,5-triphosphate (IP3) -sensitive stores, the selectivity is weak and BHQ mobilizes substantially more Ca²⁺ than does a maximally effective concentration of IP3.[1]
  
  
• CAS Reg. No. : 88-58-4
  
  
• RTECS No. : MX5160000
  
  
• Bibliography :
  
  1. Oldershaw et al., "2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-triphosphate-sensitive and -insensitive Ca²⁺ stores" FEBS Lett., (1990). 274(1-2):214-216
  2. Schilling et al., Biochem. J., (1992). 284:521
  3. Moore et al., FEBS Lett. (1987). 224:331
  4. Wictome et al., FEBS Lett. (1992). 304:109
  5. Mason et al., J. Biol. Chem. (1991). 266:20856