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Home Page > Alphabetical Index > CAFFEINE

CAFFEINE Prod. No L9080 - CAS # 58-08-2
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Product Name CAFFEINE
(Syn.: Thein; guaranine; methyltheobromide‚ 1‚3‚7-trimethylxanthine)
Product Code L9080
CAFFEINE

C8H10N4O2
Molecular Formula C8H10N4O2
Description

a CNS stimulant.

Alkaloid‚ C8H10N4O2 ‚ purified from plants of Coffea genus‚ Rubiaceae.
 
Biological Activity

A1 adenosine receptor: Ki = 29 µM; A2 adenosine receptor: Ki = 48 µM. [3]


Ca2+ channels activator: agonist of Ryanodine receptors.
 
Chemical and Physical Properties
 
CAS No. 58-08-2 Molecular Weight 194.2 Da.
RTECS EV 6475000 Physical Form white solid.
Merck Index No (13th Ed.) 1635 Melting point 234-237°C.
PubChem SID Solubility pyrrole‚ tetrahydrofuran containing approx. 4% water and ethyl acetate; moderately in water‚ ethanol and acetone.
Purity min. 99%. (TLC) Optical Activity
Toxicity (LD50) orally:hamster: 230 mg/kg; rat: 192 mg/kg; mice: 127 mg/kg;
dog: 140 mg/kg; rabbit: 224 mg/kg.

i.v.:rat: 105 mg/kg; mice: 62 mg/kg; rabbit: 58 mg/kg.

i.p.:rat: 240 mg/kg; mice: 168 mg/kg.

s.c.:rat: 170 mg/kg; mice: 242 mg/kg; dog: 100 mg/kg.
Chemical Names 3‚7-dihydro-1‚3‚7-trimethyl-IH-purine-2‚6-dione.
Storage & Reconstitution Recommendations store at room temperature‚ in a dark place.
Safety Recommendations
 
Bibliographic References
  1. Zubair et al., "Analytical profiles of drug substances", Florey Ed., Academic Press, New York, (1986). 15:71-150
  2. Saano et al.; Acta Pharmacol et toxicol. (1982). 51:300
  3. Bruns et al., Mol. Pharmacol. (1986). 29:331
  4. Pessah et al., Mol. Pharmacol. (1987). 31:232-238
 
Prices
Code
Quantity
US $
€uro
L9080
1 g
18.20
13.00
5 g
72.80
52.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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