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Home Page > Alphabetical Index > MAUROCALCINE (MCa)

MAUROCALCINE (MCa) Prod. No L8225 - CAS #
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Product Name MAUROCALCINE (MCa)
Product Code L8225
MAUROCALCINE (MCa)

Molecular Formula
Description

An activator of Ca2+ release channel/ryanodine receptors.

33-mer basic peptide cross-linked by three disulphide bridges.
Synthetic‚ from Scorpio maurus palmatus scorpion venom.

 
Biological Activity

Agonist of ryanodine receptor type 1‚ 2 and 3 - Potently and reversibly modifies channel gating behaviour of the type 1 ryanodine receptor (RyR1) by inducing increased opening probabilities and a prominent subconductance behaviour.

Binds to a different site than ryanodine.


Class of biological activity: Ca2+ channel activator.

At cellular level: Myotubes‚ HEK293 cells expressing RyR1.

Potency: EC50 at 12 to 20 nM.

Field of use: Therapeutic potential‚ notably as candidate immuno-suppressive drugs‚ and for the treatment of diseases induced by dysfunction of calcium channels‚ in man.

Research in pharmacology and physiology.

 
Chemical and Physical Properties
 
CAS No. Molecular Weight 3857.2 Da
RTECS Physical Form white powder.
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility aqueous solution.
Purity >99% Optical Activity
Toxicity (LD50) Lethal dose: 20 µg/mice (ICV).

Route of administration: Intracerebroventricular & intravenous.
Chemical Names
Storage & Reconstitution Recommendations Stable at room temperature‚ store preferably at -20°C.
Safety Recommendations Use gloves‚ wear mask‚ manipulate under hood.
 
Bibliographic References
  1. Fajloun Z, Kharrat R, Chen L et al. Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca2+ release channel / ryanodine receptors. FEBS Letters 469: 179-185 (2000).
  2. Chen L, Estève E, Sabatier JM et al. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1 (RyR1) revealing a proportional gating mechanism. Journal of Biological Chemistry 278: 16095-16106 (2003).
  3. Estève E, Smida-Rezgui S, Sarkozi S et al. Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. Journal of Biological Chemistry 278: 37822-37831 (2003).
  4. Estève E, Mabrouk K, Dupuis A et al. M.Transduction of the scorpion toxin maurocalcine into cells – Evidence that the toxin crosses the plasma membrane. Journal of Biological Chemistry 280: 12833-12839 (2003).
  5. Szappanos H, Smida-Rezgui S, Cseri J et al. Differential effects of Maurocalcine on Ca2+ release events and depolarisation induced Ca2+ release in rat skeletal muscle. Journal of Physiology 565: 843-853 (2005).
  6. Boisseau S, Mabrouk K, Garmy N et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochimica Biophysica Acta Biomembranes 1758 : 308-319 (2005).
 
Prices
Code
Quantity
US $
€uro
L8225-25UG
1 x 25 µg
280.00
200.00
5 x 25 µg
1 120.00
800.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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