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Ion Channel and Receptor Ligands
Venoms
Toxins and Alkaloids
Latoxan© August 2007 NewsLetter 07-2.
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C31H42N2O6
The most potent Na+ channel activator
BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation.
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The First Library of Venom Fractions
Natural animal peptides and toxins in 96-well-plates for
Drug Discovery and High Throughput Screening (HTS).
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KITOXAN® is a unique selection of snakes, scorpions, amphibians and spiders venoms fractions in ready-to-use 96-well-plates.
All venoms have been cleared from molecules over 8.500 Da (cytotoxic enzymes) and split up in 20 fractions. Each fraction is expected to contain at least 5 to 10 peptides at a 10µmol concentration in 100µl.
HPLC Chromatogram and MALDI-TOF mass spectrum are also provided for each venom.
read more...
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The richest honey Bee venom now available in large quantities
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Apis mellifera venom (Honey Bee) with guaranteed high contents in Apamin (~3%), Melitin (60 to 70%), MCD peptide (~3%) is available in large quantities and in several geographical origins.
read more...
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The most comprehensive choice of Crotalid species venoms
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Crotalid snakes venoms contain molecules strongly active on haemostasis. They are also responsible for a significant proportion of envenomations in man.
With over 100 different venoms LATOXAN built the largest catalogue of crotalid snakes venoms.
read more...
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C20H17NO6
Alkaloid from plants of the Corydalis genus, Fumariaceae.
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After a shortage period, d-Bicuculline is again available
d-Bicucullin is a potent antagonist of vertebrate GABAA and insect somal Ach1 receptors. Bicuculline can also be used to block small conductance Ca2+-activated potassium channels.
read more...
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Best regards
Latoxan
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Commercial Contact :
Phone : +33.(0)475.41.91.91
Fax : +33.(0)475.41.91.99
Email : contact@latoxan.com
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© 2007 Latoxan. All rights reserved. You received this editorial/commercial e-newsletter from Latoxan because the information for your account indicates that Latoxan may contact you via e-mail. To unsubscribe from this e-newsletter
please click on the unsubscribe link above or send your request to Latoxan - 20
rue Léon Blum - 26000 Valence - France. Unsubscribe
Ref. : August 2007 NewsLetter 07-2 - 05/09/2007 18:44:21
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