L8437-100UG - SNX482
SNX482 | Product ID | L8437-100UG |
| Name | SNX482 |
| Molecular formula | C192H274N52O60S7 |
| Description |
A 41 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Cameroon red baboon spider Hyterocrates gigas. |
| Biological activity | SNX482 blocks vertebrate P/Q-type (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) voltage-gated calcium channels. Also inhibits sodium channels (Nav) in bovine chromaffin cells by delaying sodium channel inactivation. SNX-482�acts rapidly and maintains its effect. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 210.00 | ||
| 5 Unité(s) | 840.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8437-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8437-100UG | Molecular weight | 4496.42 Da |
| Product name | SNX482 | Physical form | White lyophilized solid |
| CAS No. | 203460-30-4 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P56854 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90488787 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8437-100UG |
| Product name | SNX482 |
- 1. Arroyo G, et al. (2003) SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells, Eur J Pharmacol. ;
2. Bourinet, E., et al. (2001) Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels, Biophys. PMID 11423396 ;
3. Matthews EA., et al. (2007) The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. PMID 17610575 ;
4. Newcomb, R., et al. (1998) Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas, Biochemistry.
Links
| Product code | L8437-100UG |
| Product name | SNX482 |
| External Links |
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