CONOTOXIN GIIIB (mu-)
Product ID L8512-100UG 
Name CONOTOXIN GIIIB (mu-) 
Molecular formula C101H175N39O30S7
Description
A 22 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Geographer cone snail Conus geographus.
Biological activity

µ-conotoxin GIIIB selectively blocks Nav1.4 voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM. µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na+ channel.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 120.00

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5 Unité(s) 480.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8512-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8512-100UG  Molecular weight 2640.26 Da
Product name CONOTOXIN GIIIB (mu-)  Physical form White lyophilized solid
CAS No. 140678-12-2 Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P01524 Optical Activity
PubChem SID    
PubChem CID 90469965    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8512-100UG 
Product name CONOTOXIN GIIIB (mu-) 

- 1. Cruz LJ, et al. (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels. JBC.  ;
2. Gregory N. Filatov and Mark M. Rich (2004) Hyperpolarized shifts in the voltage dependence of fast inactivation of Nav1.4 and Nav1.5 in a rat model of critical illness myopathy. J. Physiol.  ;
3. Ronald A. Li, et al. (2003) Molecular Basis of Isoform-specific ?-Conotoxin Block of Cardiac, Skeletal Muscle, and Brain Na+ Channels. JBC.  ;
4. Ronald A. Li, et al. (2000) Novel Structural Determinants of m-Conotoxin (GIIIB) Block in Rat Skeletal Muscle (m1) Na+ Channels. JBC.
 Links
Product code L8512-100UG 
Product name CONOTOXIN GIIIB (mu-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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